prikaz prve stranice dokumenta Korelacije in vitro-in vivo za farmaceutske alternative dronedaron-hidroklorida
  Download
PDF 2.19 MB
master's thesis
Korelacije in vitro-in vivo za farmaceutske alternative dronedaron-hidroklorida
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. urn:nbn:hr:149:716223
Vučetić, Matea
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Vučetić, M. (2020). Korelacije in vitro-in vivo za farmaceutske alternative dronedaron-hidroklorida (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:716223

Vučetić, Matea. "Korelacije in vitro-in vivo za farmaceutske alternative dronedaron-hidroklorida." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. https://urn.nsk.hr/urn:nbn:hr:149:716223

Vučetić, Matea. "Korelacije in vitro-in vivo za farmaceutske alternative dronedaron-hidroklorida." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2020. https://urn.nsk.hr/urn:nbn:hr:149:716223

Vučetić, M. (2020). 'Korelacije in vitro-in vivo za farmaceutske alternative dronedaron-hidroklorida', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:716223

Vučetić M. Korelacije in vitro-in vivo za farmaceutske alternative dronedaron-hidroklorida [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2020 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:149:716223

M. Vučetić, "Korelacije in vitro-in vivo za farmaceutske alternative dronedaron-hidroklorida", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:149:716223

Metadata
TitleKorelacije in vitro-in vivo za farmaceutske alternative dronedaron-hidroklorida
Title (english)In vitro-in vivo correlation for pharmaceutical alternatives of dronedarone hydrochloride
AuthorMatea Vučetić
MentorGordana Matijašić (mentor)
Committee memberGordana Matijašić (predsjednik povjerenstva)
Committee memberKrunoslav Žižek (član povjerenstva)
Committee memberIgor Dejanović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2020-09-18, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Glavni cilj tijekom razvoja dozirnih oblika u farmaceutskoj industriji je dobro razumijevanje in vitro i in vivo ponašanja dozirnih oblika. Jedan od izazova tijekom istraživanja je i koreliranje in vitro ponašanja lijeka različitih formulacija s in vivo profilom – izrada in vitro–in vivo korelacija (IVIVK). Razvoj takvog alata smanjuje vrijeme razvoja lijeka, ekonomizira resurse i omogućava bolju kvalitetu proizvoda. Sve veća upotreba IVIVK govori o njihovom velikom značaju za farmaceutsku industriju. Dronedaron-hidroklorid (DNR) kao djelatna tvar korišten je za izradu farmaceutskih alternativa oralnih dozirnih oblika; peleta, 3D tiskanih tableta i kapsula te mikrokapsula oblaganih različitim polimerima. Ispitano je in vitro oslobađanje djelatne tvari, a softverom GastroPlusTM izrađene simulacije in vivo ponašanja i pripadne farmakokinetike. Na temelju dobivenih podataka izrađene su korelacije koje opisuju ponašanje pojedinog dozirnog oblika. Rezultati ispitivanja pokazali su izvrsno slaganje za impregnirane i obložene pelete manjeg sadržaja DNR, 3D tiskane kapsule s debljinom stijenke od 0,50 mm te mikrokapsule oblagane metakrilatnim kopolimerom. Za daljnja istraživanja pogodne su i 3D tablete s najmanjom gustoćom ispune (25 %) te 3D tiskane kapsule većih debljina stijenke (0,75 i 1 mm).
Abstract (english)
A key goal in pharmaceutical development of dosage forms is a good understanding of the in vitro and in vivo performance of dosage forms. One of the challenges in their research is correlating in vitro drug release information with the in vivo drug profiles – establish of in vitro–in vivo correlations (IVIVC). Such a tool shortens the drug development period, economizes the resources and leads to improved product quality. Increased activity in developing IVIVCs indicates their value to the pharmaceutical industry. Dronedarone hydrochloride was used as active pharmaceutical ingredient for making pharmaceutical alternatives of oral dosage forms; pellets, 3D printed tablets and capsules and microcapsules coated with polymers. In vitro release profiles were obtained and software GastroPlusTM was used to create simulations of in vivo behaviour and pharmacokinetics. Based on the data obtained, correlations that describe behavior of dosage forms were established. The research results showed good agreement for impregnated and coated pellets with lower dose of DNR, 3D printed capsules with 0.50 mm wall thickness and microcapsules coated with methacrylate copolymer. 3D printed tablets with 25 % of tablet infill and 3D printed capsules with thicker walls (0.75 and 1 mm) are suitable for further research.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:716223
Study programmeTitle: Chemical Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-04-21 12:41:42