prikaz prve stranice dokumenta Sinteza konjugata kinolina i harmina s potencijalnim antimalarijskim djelovanjem
  Download
PDF 1.71 MB
undergraduate thesis
Sinteza konjugata kinolina i harmina s potencijalnim antimalarijskim djelovanjem
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. urn:nbn:hr:149:667034
Štulić, Rebeka
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Štulić, R. (2018). Sinteza konjugata kinolina i harmina s potencijalnim antimalarijskim djelovanjem (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:667034

Štulić, Rebeka. "Sinteza konjugata kinolina i harmina s potencijalnim antimalarijskim djelovanjem." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. https://urn.nsk.hr/urn:nbn:hr:149:667034

Štulić, Rebeka. "Sinteza konjugata kinolina i harmina s potencijalnim antimalarijskim djelovanjem." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. https://urn.nsk.hr/urn:nbn:hr:149:667034

Štulić, R. (2018). 'Sinteza konjugata kinolina i harmina s potencijalnim antimalarijskim djelovanjem', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:667034

Štulić R. Sinteza konjugata kinolina i harmina s potencijalnim antimalarijskim djelovanjem [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2018 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:149:667034

R. Štulić, "Sinteza konjugata kinolina i harmina s potencijalnim antimalarijskim djelovanjem", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:149:667034

Metadata
TitleSinteza konjugata kinolina i harmina s potencijalnim antimalarijskim djelovanjem
Title (english)Synthesis of quinoline and harmine conjugates with potential antimalarial activity
AuthorRebeka Štulić
MentorSilvana Raić-Malić (mentor)
Committee memberSilvana Raić-Malić (predsjednik povjerenstva)
Committee memberDragana Vuk (član povjerenstva)
Committee memberLidija Furač (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2018-09-17, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
U okviru ovog rada provedena je sinteza novih potencijalno biološki aktivnih hibrida kinolina, kumarina i harmina regioselektivnom 1,3-dipolarnom cikloadicijom terminalnih alkina i organskih azida. Spojevi su priređeni konvencionalnom sintetskom metodom koja zadovoljava većinu uvjeta ,,klik“ kemije. Harmin 1 prevodi se u reakciji s propargil-bromidom u 9-(prop-2-inil)harmin 2 koji onda Huisgenovom cikloadicijom s kumarinskim 3 i kinolinskim azidom 4 kataliziranom bakrom(I) daje odgovarajuće 1,2,3-triazolne konjugate 5 i 6. Polazni alkini 8 i 11 za sintezu kumarinskih i kinolinskih 1,2,3-triazola 7-(prop-2-iniloksi)harmina 9, 10 i 9-(prop-2-inil)-7-(prop-2-iniloksi)harmina 12, 13 dobivaju se iz harmola 7. Priređenim spojevima 5, 6, 9, 10, 12 i 13 ispitat će se antimalarijska aktivnost.
Abstract (english)
The aim of this work was the synthesis of novel hybrids containing coumarine, quinoline and harmine moiety with potential biological activity, using regioselective 1,3-dipolar cycloaddition of terminal alkynes and organic azides. Novel compounds were prepared by conventional synthetic approach which fulfills most of ,,click“ chemistry requirements. Harmine 1 is converted with propargyl-bromide to 9-(prop-2-ynyl)harmine 2 which then in Huisgen copper(I) catalyzed cycloaddition with coumarine 3 and quinoline 4 azide gives corresponding 1,2,3-triazole conjugates 5 and 6. Alkynes 8 and 11 needed for the synthesis of coumarine and quinoline 1,2,3-triazoles 7-(prop-2-ynyloxy)harmines 9, 10 and 9-(prop-2-ynyl)-7-(prop-2-ynyloxy)harmines 12, 13 are synthesized starting from harmole 7. Antimalarial activity of prepared compounds 5, 6, 9, 10, 12 and 13 will be performed.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:667034
ProjectNumber: IP-2013-11-5596
Title: Sinteza i citostatska ispitivanja biblioteke novih dušikovih heterocikla
Title: Synthesis and cytostatic evaluations of novel nitrogen heterocycles library
Acronym: SCIENcENTRY
Leader: Silvana Raić-Malić
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-05-10 11:37:47