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undergraduate thesis
Mikroemulzije kao sustav za dostavu lijeka
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. urn:nbn:hr:149:649188
Leskovar, Monika
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Leskovar, M. (2018). Mikroemulzije kao sustav za dostavu lijeka (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:649188

Leskovar, Monika. "Mikroemulzije kao sustav za dostavu lijeka." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. https://urn.nsk.hr/urn:nbn:hr:149:649188

Leskovar, Monika. "Mikroemulzije kao sustav za dostavu lijeka." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2018. https://urn.nsk.hr/urn:nbn:hr:149:649188

Leskovar, M. (2018). 'Mikroemulzije kao sustav za dostavu lijeka', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:649188

Leskovar M. Mikroemulzije kao sustav za dostavu lijeka [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2018 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:149:649188

M. Leskovar, "Mikroemulzije kao sustav za dostavu lijeka", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:149:649188

Metadata
TitleMikroemulzije kao sustav za dostavu lijeka
Title (english)Self-microemulsifying drug delivery system
AuthorMonika Leskovar
MentorGordana Matijašić (mentor)
Committee memberGordana Matijašić (predsjednik povjerenstva)
Committee memberKrunoslav Žižek (član povjerenstva)
Committee memberJuraj Šipušić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2018-09-19, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Mechanical, Thermal and Separation Processes
Abstract
Mikroemulzije su se u proteklih nekoliko godina pojavile kao novi dozirni oblik kojim se omogućuje povećanje apsorpcije djelatne tvari u organizam. To su termodinamički stabilni, optički izotropni sustavi sastavljeni od ulja, vode, surfaktanata i kosurfaktanata. Zbog postojanja hidrofilnih i lipofilnih domena pokazuju poboljšanu topljivost djelatne tvari. Prema strukturi dijele se na mikroemulzije ulja u vodi, mikroemulzije vode u ulju te bikontinuirane strukture. U eksperimentalnom su istraživanju formirane samoorganizirajuće mikroemulzije s uklopljenim dronedaron-hidrokloridom. Dronedaron-hidroklorid otopljen je u etanolu koji je uklonjen isparavanjem u rotacijskom isparivaču i vakuumskom sušioniku. Korištena su dva stabilizatora, Kolliphor EL i Kolliphor RH40. In vitro metodom ispitana je brzina oslobađanja dronedaron-hidroklorida iz mikroemulzija. Promjena koncentracije dronedarona određena je pomoću UV/Vis spektrofotometra mjerenjem apsorbancije te su dobiveni profili oslobađanja dronedaron-hidroklorida. Mikrografijama je potvrđeno da dodatkom pripremljenog sustava u fosfatni pufer nastaju mikroemulzije. In vitro metoda ispitivanja pokazala je izuzetno brzo oslobađanje dronedaron-hidroklorida iz mikroemulzija, već 90 % nakon 10 minuta.
Abstract (english)
In last few years, microemulsions have been recognized as new alternative dosage form which allows increase in the absorption of active substance. They are thermodynamically stable, optically isotropic systems of oil, water, surfactants and cosurfactants. Due to the existence of hydrophilic and lipophilic domains better solubility of active substances is possible. Structurally, they are divided into oil in water, water in oil and bicontinuous microemulsions. Self-microemulsifying drug delivery systems containing dronedarone hidrochloride were prepared in this study. Dronedarone hydrochloride was dissolved in ethanol and then removed by evaporation in rotational evaporator and vacuum dryer. Two stabilizers were used, Kolliphor EL i Kolliphor RH40. In vitro method was used to determine the release rate of dronedarone hydrochloride from microemulsions. The change of dronedarone concentration was determined measuring the absorbance by UV/Vis spectrophotometer. Also, dronedarone hydrochloride dissolution profiles were obtained. Micrographs confirmed self-formation of microemulsions when prepared mixtures were added into phosphate buffer. In vitro method showed instant release of dronedarone hydrochloride from microemulsions, 90% after 10 minutes.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:649188
Study programmeTitle: Chemical Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2022-05-20 12:01:00