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undergraduate thesis
Polimeri za dostavu lijeka s kontroliranim oslobađanjem
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. urn:nbn:hr:149:495560
Banožić, Benjamin
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Banožić, B. (2019). Polimeri za dostavu lijeka s kontroliranim oslobađanjem (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:495560

Banožić, Benjamin. "Polimeri za dostavu lijeka s kontroliranim oslobađanjem." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:495560

Banožić, Benjamin. "Polimeri za dostavu lijeka s kontroliranim oslobađanjem." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:495560

Banožić, B. (2019). 'Polimeri za dostavu lijeka s kontroliranim oslobađanjem', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 23 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:495560

Banožić B. Polimeri za dostavu lijeka s kontroliranim oslobađanjem [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2019 [cited 2024 November 23] Available at: https://urn.nsk.hr/urn:nbn:hr:149:495560

B. Banožić, "Polimeri za dostavu lijeka s kontroliranim oslobađanjem", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:149:495560

Metadata
TitlePolimeri za dostavu lijeka s kontroliranim oslobađanjem
Title (english)Polymers for drug delivery applications
AuthorBenjamin Banožić
MentorAnte Jukić (mentor)
Committee memberAnte Jukić (predsjednik povjerenstva)
Committee memberFabio Faraguna (član povjerenstva)
Committee memberMirela Leskovac (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2019-09-13, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
U ovom radu provedena je sinteza i karakterizacija kopolimera za oblikovanje farmaceutskih proizvoda. Sintetizirano je sedam kopolimera metil-metakrilata i vinil-pirolidona u različitim molarnim udjelima radikalskom polimerizacijom u otapalu butanolu. Dobiveni kopolimeri karakterizirani su sljedećim metodama: GPC (kromatografija na propusnom gelu) analiza, DSC (diferencijalna pretražna kalorimetrija) analiza, FTIR (infracrvena spektroskopija s Fourierovom transformacijom) analiza te TGA (termogravimetrijska analiza). Nakon sinteze i karakterizacije, pripremljene su polimerne otopine kopolimera u svrhu oblaganja djelatne tvari koje bi kasnije služile za razvoj farmaceutskih oblika s kontroliranim oslobađanjem lijeka. Analizom rezultata ustanovljeno je da smanjenje udjela metil-metakrilata, a povećanje vinil-pirolidona u kopolimeru doprinosi homogenosti i stabilnosti otopina. Upravo takvi stabilni sustavi su pogodni za oblaganje farmaceutika za kontrolirano otpuštanje kroz dulje razdoblje, dostavu lijeka na određeno mjesto te mogućnost prepoznavanja i reagiranja na fiziološke promjene u ljudskom organizmu.
Abstract (english)
This work presents the synthesis and characterisation of copolymers which are used for formatting pharmaceutical products. Seven copolymers were synthesized with various molar contents of methyl methachrylate and vinyl pyrrolidon by reaction of radical polymerization in butanol. Obtained copolymers were characterized by following methods: GPC analysis (gel permeation chromatography), DSC analysis (differential scanning calorimetry), FTIR analysis (Fourier-transform infrared spectroscopy) and TGA (thermogravimetric analysis). After synthesis and characterisation, polymer solutions of copolymers were prepared in order to sheathe active substances which can be used for development of pharmaceutical forms by controlled drug release. Results indicate that decrease of copolymer methyl methachrylate and increase of vinyl pyrrolidon contents in copolymer contribute to homogeneity and stability of solution. Those stable systems are suitable for sheathing pharmaceuticals over a long period, drug delivery to a specific location. Furthermore, they are suitable for identification and respond to physiological changes in human body.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:495560
Study programmeTitle: Chemical Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
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Created on2023-02-13 12:14:25