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undergraduate thesis
Sprega metode uklanjanja otapala i taljenja za pripravu čvrste disperzije djelatne tvari
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. urn:nbn:hr:149:325515
Adamić-Golić, Melani
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Adamić Golić, M. (2022). Sprega metode uklanjanja otapala i taljenja za pripravu čvrste disperzije djelatne tvari (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:325515

Adamić Golić, Melani. "Sprega metode uklanjanja otapala i taljenja za pripravu čvrste disperzije djelatne tvari." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:149:325515

Adamić Golić, Melani. "Sprega metode uklanjanja otapala i taljenja za pripravu čvrste disperzije djelatne tvari." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:149:325515

Adamić Golić, M. (2022). 'Sprega metode uklanjanja otapala i taljenja za pripravu čvrste disperzije djelatne tvari', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 29 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:325515

Adamić Golić M. Sprega metode uklanjanja otapala i taljenja za pripravu čvrste disperzije djelatne tvari [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2022 [cited 2024 December 29] Available at: https://urn.nsk.hr/urn:nbn:hr:149:325515

M. Adamić Golić, "Sprega metode uklanjanja otapala i taljenja za pripravu čvrste disperzije djelatne tvari", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:149:325515

Metadata
TitleSprega metode uklanjanja otapala i taljenja za pripravu čvrste disperzije djelatne tvari
Title (english)Coupling solvent removal and fusion method to prepare solid dispersion of drug
AuthorMelani Adamić-Golić
MentorKrunoslav Žižek (mentor)
Committee memberKrunoslav Žižek (predsjednik povjerenstva)
Committee memberIrena Škorić (član povjerenstva)
Committee memberVesna Ocelić Bulatović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2022-09-09, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Lurasidon-hidroklorid je antipsihotik koji se koristi za liječenje shizofrenije i bipolarnog poremećaja. Karakterizira ga slaba topljivost u intestinalnim fluidima, a time i slaba apsorpcija djelatne tvari u organizmu. Povećanje topljivosti lurasidon-hidroklorida, te samim time i bioraspoloživosti lijeka, znači bolje farmakološko djelovanje u liječenju psihičkih bolesti. Obećavajući pristup povećanju topljivosti, slabo topljivih, djelatnih tvari je priprava čvrstih disperzija. U ovom radu, čvrste disperzije hidrofobnog lurasidon-hidroklorida, u hidrofilnom, polimernom nosaču poli(etilen-glikolu), pripravljaju se u različitim omjerima spregom metode uklanjanja otapala i taljenja. Dobivene čvrste disperzije karakterizirane su diferencijalnom pretražnom kalorimetrijom, rendgenskom difrakcijskom analizom praha i infracrvenom spektroskopijom. Spektroskopske analize potvrđuju da nema amorfizacije za ovu metodu priprave niti međumolekulskih interakcija između lurasidon-hidroklorida i poli(etilen-glikola). Toplinska analiza dokazala je postojanje različitih kristalnih formi u čvrstim disperzijama.
Abstract (english)
Lurasidone hydrochloride is an antipsychotic drug used for the treatment of shizophrenia and bipolar disorder. It is characterized by low solubility in intestinal fluids and thus poor absorption of drug in the organism. Solubility improvement of lurasidone hydrochloride and thus the bioavaliability of drug, means its better pharmacological response in the treatment of psychotic disorders. Promising approach for drug solubility enhacement of poorly soluble drugs is preparation of solid dispersions. In this research, solid dispersions of hydrophobic lurasidone-hydrochloride in a hydrophilic polymer carrier poly(ethylene glycol), are to be made, in different ratios, by coupling solvent removal and fusion method. Obtained solid dispersions were characterized by differential scanning calorimetry, X-ray powder difraction analysis and infrared spectroscopy. Spectroscopic analyses confirmed that there is no amorphization for this preparation method and there is no intermolecular interactions between lurasidone-hydrochloride and poly(ethylene glycol). Thermal analysis proved the existence of different crystalline forms in solid dispersions.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:325515
Study programmeTitle: Chemical Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2022-09-09
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Created on2023-02-17 13:04:03