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undergraduate thesis
Novi amino-heterostilbeni s potencijalnom inhibicijskom i protuupalnom aktivnosti. Sinteza i fotokemija
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. urn:nbn:hr:149:516954
Goričanec, Rafael
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Goričanec, R. (2022). Novi amino-heterostilbeni s potencijalnom inhibicijskom i protuupalnom aktivnosti. Sinteza i fotokemija (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:516954

Goričanec, Rafael. "Novi amino-heterostilbeni s potencijalnom inhibicijskom i protuupalnom aktivnosti. Sinteza i fotokemija." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:149:516954

Goričanec, Rafael. "Novi amino-heterostilbeni s potencijalnom inhibicijskom i protuupalnom aktivnosti. Sinteza i fotokemija." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:149:516954

Goričanec, R. (2022). 'Novi amino-heterostilbeni s potencijalnom inhibicijskom i protuupalnom aktivnosti. Sinteza i fotokemija', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:516954

Goričanec R. Novi amino-heterostilbeni s potencijalnom inhibicijskom i protuupalnom aktivnosti. Sinteza i fotokemija [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2022 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:516954

R. Goričanec, "Novi amino-heterostilbeni s potencijalnom inhibicijskom i protuupalnom aktivnosti. Sinteza i fotokemija", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:149:516954

Metadata
TitleNovi amino-heterostilbeni s potencijalnom inhibicijskom i protuupalnom aktivnosti. Sinteza i fotokemija
Title (english)New amino heterostilbenes with potential inhibitory and anti-inflammatory activity. Synthesis and photochemistry
AuthorRafael Goričanec
MentorIrena Škorić (mentor)
Committee memberIrena Škorić (predsjednik povjerenstva)
Committee memberDragana Vuk (član povjerenstva)
Committee memberDomagoj Vrsaljko (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2022-09-01, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U ovom završnom radu provedena je sinteza i spektroskopska karakterizacija novih supstituiranih derivata amino-heterostilbena kao potencijalno biološki aktivnih molekula. Sinteza novih amino-heterostilbena provedena je u nekoliko koraka. Wittigovom reakcijom dobiveni su cis- i trans-heterostilbeni iz tiofen-2-karbaldehida i 1-brom-2-(4-klorbenzil)fosfonijeve soli, koji su u sljedećem koraku reakcijom Buchwald-Hartwigovog aminiranja prevedeni u spojeve 2-6. Novonastali spojevi pročišćeni su uzastopnom kolonskom i tankoslojnom kromatografijom pomoću preparativnih ploča obloženih silikagelom. Dobiveni produkti uspješno su izolirani i okarakterizirani spektroskopskim metodama. Prilikom izrade ovog završnog rada ukupno je dobiveno deset amino-heterostilbena, te pet elektrociklizacijskih produkata.
Abstract (english)
In this final work, the synthesis and spectroscopic characterization of new substituted derivatives of amino-heterostilbene were performed as potential biologically active molecules. The Wittig reaction gave cis- and trans-heterostilbenes from thiophene-2-carbaldehyde and 1-bromo-2-(4-chlorobenzyl)phosphonium salt, which were converted into compounds 2-6 by the Buchwald-Hartwig amination reaction in the second step. The newly formed compounds were purified by repeated column and thin-layer chromatography using preparative plates coated with silica gel. The obtained products were successfully isolated and characterized by spectroscopic methods. During the preparation of this work, a total of ten amino-heterostilbenes and five electrocyclization products were obtained.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:516954
Study programmeTitle: Materials Science and Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2023-02-23 11:29:55