Since the early 1990-s, neonicotinoid pesticides have been widely used as an effective agent against insects harmful to plants. Due to bioaccumulation and low biodegradability, some of the neonicotinoids can often be found in surface and underground water, which can poses a great danger to people and the environment. Consequently, there is a need for the development and application of advanced technologies for their degradation or other form of their removal from the environment. Achievements in the field of heterogeneous photocatalysis contribute significantly to environmental remediation, however, despite the great effectiveness of such processes, there is still a need to overcome certain challenges and obstacles realted to their application in real systems. This paper examined the photocatalytic degradation of acetamiprid in a rotating photoreactor. Special emphasis is given to the influence of applied persulfates on the photodegradation efficiency of the mentioned model component. Photodegradation was carried out in batch conditions, using an immobilized layer of TiO2 photocatalyst that was previously modified by UVC radiation with the aim of reducing the energy gap. The initial concentration of acetamiprid was 10 ppm and the reaction mixture circulated through the system using a recirculation pump at a flow rate of 200 ml/min. The photocatalyst was exposed to UV radiation, while the photoreactor tube rotated at a controlled speed of 200 revolutions/min. The total duration of the reaction (i.e. radiation) was 4 hours, with an additional 30 minutes needed to achieve equilibrium adsorption of the model component on the surface of the photocatalyst. The degradation of acetamiprid was monitored using high-performance liquid chromatography (HPLC) with periodic sampling of 1 mL volume. Based on the obtained results, it can be concluded that the degradation of acetamiprid is carried out more successfully in the presence of TiO2-UVC photocatalyst compared to photolytic degradation. The presence of persulfate (PS), eg potassium persulfate (K2S2O8) and peroxymonosulfate (PMS), eg potassium peroxymonosulfate (KHSO5) leads to a significant improvement in the overall photodegradation efficiency of acetamiprid. A kinetic analysis was carried out using an empirical kinetic model for the first-order reaction, which was included in the model of the boiler reactor, with the root mean square deviation as measure of the differences between values, whereby a good match between experimental and theoretical results was found. Characteristic photodegradation rate constants and characteristic half-lives were also calculated.