prikaz prve stranice dokumenta Određivanje minimalne inhibitorne koncentracije 2-aril supstituiranih derivata benzimidazola na E. coli (ATCC 25922), E. faecalis (ATCC 29212), K. pneumoniae (ATCC 27736), P. aeruginosa (ATCC 9027) i S. aureus (ATCC 25923)
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undergraduate thesis
Određivanje minimalne inhibitorne koncentracije 2-aril supstituiranih derivata benzimidazola na E. coli (ATCC 25922), E. faecalis (ATCC 29212), K. pneumoniae (ATCC 27736), P. aeruginosa (ATCC 9027) i S. aureus (ATCC 25923)
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. urn:nbn:hr:149:962528
Kuzmić, Leona
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Kuzmić, L. (2022). Određivanje minimalne inhibitorne koncentracije 2-aril supstituiranih derivata benzimidazola na E. coli (ATCC 25922), E. faecalis (ATCC 29212), K. pneumoniae (ATCC 27736), P. aeruginosa (ATCC 9027) i S. aureus (ATCC 25923) (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:962528

Kuzmić, Leona. "Određivanje minimalne inhibitorne koncentracije 2-aril supstituiranih derivata benzimidazola na E. coli (ATCC 25922), E. faecalis (ATCC 29212), K. pneumoniae (ATCC 27736), P. aeruginosa (ATCC 9027) i S. aureus (ATCC 25923)." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:149:962528

Kuzmić, Leona. "Određivanje minimalne inhibitorne koncentracije 2-aril supstituiranih derivata benzimidazola na E. coli (ATCC 25922), E. faecalis (ATCC 29212), K. pneumoniae (ATCC 27736), P. aeruginosa (ATCC 9027) i S. aureus (ATCC 25923)." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:149:962528

Kuzmić, L. (2022). 'Određivanje minimalne inhibitorne koncentracije 2-aril supstituiranih derivata benzimidazola na E. coli (ATCC 25922), E. faecalis (ATCC 29212), K. pneumoniae (ATCC 27736), P. aeruginosa (ATCC 9027) i S. aureus (ATCC 25923)', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:962528

Kuzmić L. Određivanje minimalne inhibitorne koncentracije 2-aril supstituiranih derivata benzimidazola na E. coli (ATCC 25922), E. faecalis (ATCC 29212), K. pneumoniae (ATCC 27736), P. aeruginosa (ATCC 9027) i S. aureus (ATCC 25923) [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2022 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:962528

L. Kuzmić, "Određivanje minimalne inhibitorne koncentracije 2-aril supstituiranih derivata benzimidazola na E. coli (ATCC 25922), E. faecalis (ATCC 29212), K. pneumoniae (ATCC 27736), P. aeruginosa (ATCC 9027) i S. aureus (ATCC 25923)", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:149:962528

Metadata
TitleOdređivanje minimalne inhibitorne koncentracije 2-aril supstituiranih derivata benzimidazola na E. coli (ATCC 25922), E. faecalis (ATCC 29212), K. pneumoniae (ATCC 27736), P. aeruginosa (ATCC 9027) i S. aureus (ATCC 25923)
Title (english)Determination of minimal inhibitory concentration of 2-aryl supstituted benzimidazole derivatives on E. coli (ATCC 25922), E. faecalis (ATCC 29212), K. pneumoniae (ATCC 27736), P. aeruginosa (ATCC 9027) and S. aureus (ATCC 25923)
AuthorLeona Kuzmić
MentorDajana Kučić Grgić (mentor)
Committee memberDajana Kučić Grgić (predsjednik povjerenstva)
Committee memberVesna Ocelić Bulatović (član povjerenstva)
Committee memberLidija Furač (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2022-09-16, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Sve veći ubrzani porast bakterijske rezistencije danas predstavlja jedan od važnijih problema s kojim se čovječanstvo susreće stoga je sve veća potreba za sintezom novih spojeva koji imaju inhibitorno djelovanje. Derivati heterocikličkih spojeva, benzimidazoli i benzotiazoli, predstavljaju potencijalno biološki aktivne agense stoga je sve veći interes za njihovu sintezu i proučavanje antimikrobnog djelovanja. U okviru ovog rada određena je minimalna inhibitorna koncentracija (MIC) 2-aril supstituiranih derivata benzimidazola na Gram pozitivne bakterije, Enterococcus faecalis (ATCC 29212) i Staphylococcus aureus (ATCC 25923), i Gram negativne bakterije, Escherichia coli (ATCC 25922), Klebsiella pneumoniae (ATCC 27736) i Pseudomonas aeruginosa (ATCC 9027). U tu svrhu primijenjena je makrodilucijska metoda pri čemu je spektrofotometrijski određena minimalna inhibitorna koncentracija. Provedbom eksperimenta i usporedbom rezultata dolazi se do zaključka da određeni derivati benzimidazola inhibiraju rast mikroorganizama korištenih u ovom radu u određenim koncentracijama. Prema rezultatima, vidljivo je da dobro inhibitorno djelovanje ima spoj 4-(2-(4-(6-chloro-1H-benzo[d]imidazol-2-il)fenoksi)etil)morfolin prema bakteriji E.faecalis, MIC=0,25 mg/L i S.aureus, MIC=32 mg/L. Spojevi 4-(2-(4-((4-(1H-benzo[d]imidazol-2-il)fenoksi)metil)-1H-1,2,3-triazol-1-il)etil)morfolin i 2-(4-(6-chloro-1H-benzo[d]imidazol-2-il)fenoksi)-N,N-dietiletan-1-amin također su pokazali dobro inhibitorno djelovanje prema E. faecalis i S. aureus, MIC=0,25 mg/L.
Abstract (english)
One of the most important problems facing humanity today is accelerated growth of bacterial resistance, therefore there is a growing need for the synthesis of new compounds that have an inhibitory effect. Derivates of heterocyclic compounds, benzimidazoles and benzothiazoles, represent potentially biologically active agents, therefore there is a growing interest in their synthesis and study od antimicrobial activity. This work presents the minimum inhibitory concentration of 2-aryl substituted benzimidazoles on Gram positive bacteries Enterococcus faecalis (ATCC 29212) and Staphylococcus aureus (ATCC 25923) and Gram negative bacteries Escherichia coli (ATCC 25922), Klebsiella pneumoniae (ATCC 27736) and Pseudomonas aeruginosa (ATCC 9027). For this purpose, was used macrodilution method and the minimum inhibitory concentration was determined spectrophotometrically. By conducting experiments and comparing the results, we came to the conclusion that certain benzimidazole derivates in certain concentrations inhibit the growth of microorganisms which were used in this work. According to the results, it is evident that the compound 4-(2-(4-(6-chloro-1H-benzo[d]imidazol-2-yl)phenoxy)ethyl)morpholine has a good inhibitory effect against the bacteria E. faecalis, MIC=0.25 mg/L and S. aureus, MIC=32 mg/L. Compounds 4-(2-(4-((4-(1H-benzo[d]imidazol-2-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)ethyl)morpholine and 2-(4-(6-chloro-1H-benzo[d]imidazol-2-yl)phenoxy)-N,N-diethylethane-1-amine also showed good inhibitory activity against E. faecalis and S. aureus, MIC=0.25 mg/L.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:962528
ProjectNumber: IP-2018-01-4682
Title: Novi spojevi temeljeni na bioizosterima purina za ispitivanje njihovih antitumorskih i antipatogenih djelovanja
Acronym: PurBioCaPa
Leader: Silvana Raić-Malić
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Environmental Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva)
Type of resourceText
File originBorn digital
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Created on2023-03-02 08:29:16