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master's thesis
Vođenje procesa kristalizacije aktivnih farmaceutskih tvari
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. urn:nbn:hr:149:395402
Sejdić, Marko
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Sejdić, M. (2022). Vođenje procesa kristalizacije aktivnih farmaceutskih tvari (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:395402

Sejdić, Marko. "Vođenje procesa kristalizacije aktivnih farmaceutskih tvari." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:149:395402

Sejdić, Marko. "Vođenje procesa kristalizacije aktivnih farmaceutskih tvari." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:149:395402

Sejdić, M. (2022). 'Vođenje procesa kristalizacije aktivnih farmaceutskih tvari', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 23 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:395402

Sejdić M. Vođenje procesa kristalizacije aktivnih farmaceutskih tvari [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2022 [cited 2024 November 23] Available at: https://urn.nsk.hr/urn:nbn:hr:149:395402

M. Sejdić, "Vođenje procesa kristalizacije aktivnih farmaceutskih tvari", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:149:395402

Metadata
TitleVođenje procesa kristalizacije aktivnih farmaceutskih tvari
Title (english)Crystallization control of active pharmaceutical ingredients
AuthorMarko Sejdić
MentorNenad Bolf (mentor)
Committee memberNenad Bolf (predsjednik povjerenstva)
Committee memberJasna Prlić Kardum (član povjerenstva)
Committee memberIgor Dejanović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2022-07-14, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Šaržna kristalizacija jedan je od najvažnijih toplinsko-separacijskih procesa kojim se ostvaruje visoka čistoća u proizvodnji specijalnih kemikalija, hrane i farmaceutskih proizvoda. U svrhu poboljšavanja vođenja procesa kristalizacije djelatne tvari, izrađen je program koji na primjeru kalijevog sulfata izračunava temperaturni profil koji, što je bolje moguće, ispunjava funkciju cilja kojom se definira omjer veličina kristala nastalih nukleacijom i onih dodanih cijepljenjem (na kraju procesa). Taj program primjenjuje se za simuliranje i razvoj laboratorijskog sustava za vođenje šaržne kristalizacije hlađenjem. Izvedeni algoritam primjenjuje model momenta za kontinuiranu procjenu prosječne dimenzije i količine nastalih kristala rješavanjem sustava običnih diferencijalnih jednadžbi. Program uz temperaturni profil računa i koncentraciju otopine, relativno prezasićenje i karakteristične veličine vezane uz dimenzije kristala tijekom odvijanja procesa. Rješenja dobivena ovim programom ukazuju na njegovu primjenjivost za vođenje kristalizacije djelatnih tvari.
Abstract (english)
Batch crystallization is one of the most important heat-separation processes that achieve high purity in the production of special chemicals, food and pharmaceutical products. In order to improve the control of the crystallization process of active pharmaceutical ingredients, a program was created that using the example of potassium sulfate, calculates a temperature profile that fulfills the objective function defined with the ratio of size of crystals formed by nucleation and those formed by seeding (at the end of the process). This program is used to simulate and develop a laboratory system for conducting batch crystallization by cooling. The derived algorithm applies the method of moments for continuous estimation of the average dimensions and amount of formed crystals by solving a system of ordinary differential equations. The program calculates the temperature profile alongside of the solution concentration, relative supersaturation and characteristic sizes related to the crystal dimensions during the process. The solutions obtained by this program indicate its applicability for guiding the crystallization of active pharmaceutical ingredients.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:395402
ProjectNumber: KK.01.1.1.07.0017
Title: Napredno vođenje procesa kristalizacije
Title: Advanced Control of Crystallization Process
Acronym: CrystAPC
Leader: Nenad Bolf
Jurisdiction: Croatia
Funder: EK
Funding stream: EFRR
Study programmeTitle: Chemical Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-03-10 13:51:30