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undergraduate thesis
Razvoj i validacija kromatografske metode za određivanje diklofenaka u vodi
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. urn:nbn:hr:149:263701
Vukovinski, Petra
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Vukovinski, P. (2022). Razvoj i validacija kromatografske metode za određivanje diklofenaka u vodi (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:263701

Vukovinski, Petra. "Razvoj i validacija kromatografske metode za određivanje diklofenaka u vodi." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:149:263701

Vukovinski, Petra. "Razvoj i validacija kromatografske metode za određivanje diklofenaka u vodi." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:149:263701

Vukovinski, P. (2022). 'Razvoj i validacija kromatografske metode za određivanje diklofenaka u vodi', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:263701

Vukovinski P. Razvoj i validacija kromatografske metode za određivanje diklofenaka u vodi [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2022 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:263701

P. Vukovinski, "Razvoj i validacija kromatografske metode za određivanje diklofenaka u vodi", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:149:263701

Metadata
TitleRazvoj i validacija kromatografske metode za određivanje diklofenaka u vodi
Title (english)Development and validation of chromatographic method for the determination of diclofenac in water
AuthorPetra Vukovinski
MentorDragana Mutavdžić Pavlović (mentor)
Committee memberDragana Mutavdžić Pavlović (predsjednik povjerenstva)
Committee memberSandra Babić (član povjerenstva)
Committee memberMarijana Hranjec (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2022-07-06, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Validacija, tj. vrednovanje svih bitnih postupaka analitičkog sustava, predstavlja prvi korak kojim se određuje i dokumentira prikladnost analitičkog sustava za određenu namjenu. Kako bi validirali analitički sustav potrebno je ispitati izvedbene značajke kao što su: linearnost, točnost, specifičnost/selektivnost, granicu detekcije i granicu kvantifikacije, robusnost, radno područje, preciznost i osjetljivost. Cilj ovoga rada bio je osmisliti i validirati kromatografsku metodu za određivanje farmaceutika diklofenaka u izvorskoj i MilliQ vodi te se upoznati s izvedbenim značajkama analitičkog sustava. U ovome je radu opisana priprema otopina diklofenaka u izvorskoj i MilliQ vodi te je analiza provedena na tekućinskom kromatografu visoke učinkovitosti uz detektor s nizom dioda (HPLC-DAD). Rezultati analize potvrdili su da je ispitana kromatografska metoda valjana za određivanje diklofenaka u vodi jer su gotovo sve izvedbene značajke zadovoljile kriterij.
Abstract (english)
Validation, i.e., evaluation of all relevant procedures of the analytical system, represents the first step to determining and documenting the suitability of the analytical system for a specific purpose. Performance parameters such as linearity, accuracy, specificity/selection, limit of detection and limit of quantitation, robustness, work area, precision, and sensitivity need to be examined to validate. This work aims to develop and validate a chromatographic method for the determination of diclofenac in spring water and MilliQ water and become familiar with the performance parameters of the analytical system. In this work, the preparation of diclofenac solutions in spring water and MilliQ water is described. The analysis was performed on a high-performance liquid chromatograph coupled to a diode array detector (DAD). The research results have confirmed that the tested method is acceptable for the determination of diclofenac in water because almost all parameters met the criterion.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:263701
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Environmental chemistry and green technologies
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2023-02-28
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Created on2023-03-15 09:51:08