Polymers are organic substances with a large molecular weight, they are built from units or smaller repeating units connected by covalent bonds. Due to the different properties possessed by polymers, they are widely used in various industries. Polyethylene (PE) is one of the most commonly used polymers. It is thermoplastic and easy to process, flexible, resistant to low temperatures, tensile stresses and abrasion, and has low thermal conductivity. Microplastics is a term that most often refers to plastic particles with a diameter of less than 5 mm, depending on the source of formation, microplastics are divided into two types: primary and secondary microplastics. Degradation of plastic disrupts its polymer structure and changes its physical, chemical and other properties. Aging of plastic, or surface decomposition, is an irreversible process during which the characteristic chemical and physical properties of plastic change. Industry and agriculture are mainly responsible for man-made pollution. Environmental pollution is categorically divided into two types: organic and inorganic. The main causes of organic pollution are pesticides, synthetic dyes and pharmaceuticals. Pharmaceuticals/drugs are substances or mixtures of different substances that are used to prevent, alleviate and treat diseases in humans and animals in certain quantities and under certain conditions. The aim of this work was to examine the kinetics and adsorption capacity of organic pollutants, pharmaceuticals diclofenac and ciprofloxacin on aged polyethylene microparticles. High-density polyethylene, unaged (HDPE 0) and aged for 56 days (HDPE UV 56) under UV radiation, was used. FTIR analysis was performed to determine the change in the intensity of the characteristic peaks for the mentioned types of microplastics. The change in the concentration of the tested pharmaceuticals was monitored by high-performance liquid chromatography with a diode array detector. The FTIR analysis determined the characteristic bands of polyethylene, and the obtained spectrum shows a decrease in the intensity of the peaks for the aged sample, which indicates the degradation of microplastics. Using the linear regression of the dependence of log (qe) on log (Ce), the values of the correlation coefficient (R^2) were determined, which determined the Freundlich model as the most suitable model for the description of adsorption mechanisms. The obtained values of the coefficient n are between 1 and 2, which indicates a moderately favorable physical process.