prikaz prve stranice dokumenta Novi derivati benzoksazola: sinteza i strukturna karakterizacija
Embargo period 2025-10-01
undergraduate thesis
Novi derivati benzoksazola: sinteza i strukturna karakterizacija
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. urn:nbn:hr:149:364276
Jelčić, Antonija
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Jelčić, A. (2021). Novi derivati benzoksazola: sinteza i strukturna karakterizacija (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:364276

Jelčić, Antonija. "Novi derivati benzoksazola: sinteza i strukturna karakterizacija." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:364276

Jelčić, Antonija. "Novi derivati benzoksazola: sinteza i strukturna karakterizacija." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:364276

Jelčić, A. (2021). 'Novi derivati benzoksazola: sinteza i strukturna karakterizacija', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:364276

Jelčić A. Novi derivati benzoksazola: sinteza i strukturna karakterizacija [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2021 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:149:364276

A. Jelčić, "Novi derivati benzoksazola: sinteza i strukturna karakterizacija", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:149:364276

Metadata
TitleNovi derivati benzoksazola: sinteza i strukturna karakterizacija
Title (english)The novel benzoxazole derivatives: synthesis and structural characterization
AuthorAntonija Jelčić
MentorTatjana Gazivoda Kraljević (mentor)
Committee memberTatjana Gazivoda Kraljević (predsjednik povjerenstva)
Committee memberSilvija Maračić (član povjerenstva)
Committee memberDragana Mutavdžić Pavlović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2021-09-17, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U ovom radu opisana je sinteza novih derivata benzoksazola i njihova strukturna karakterizacija 1H- i 13C-NMR spektroskopijom. Reakcijom 4-hidroksibenzaldehida i odgovarajućih alkilirajućih reagenasa pripravljeni su O-alkilirani benzaldehidi (1-6) kao prekurosri koji su zatim s različito supstituiranim ortho-aminofenolima prevedeni u derivate Schiffovih baza (7-19). Oksidativnom ciklizacijom Schiffovih baza sintetizirani su derivati benzoksazola (20-32). Mikrovalno potpomognutim O-propargiliranjem 4-(5-metoksibenzo[d]oksazol-2-il)fenola (32) s propargil-bromidom uz kalijev karbonat kao bazu sintetiziran je 5-metoksi-2-(4-(prop-2-in-1-iloksi)fenil)benzo[d]oksazol (33) koji je potom klik reakcijom 1,3-dipolarne cikloadicije katalizirane bakrovim(I) jodidom s prethodno dobivenim azidima (34-36) preveden u 1,2,3-triazolne derivate benzoksazola (37-39). Strukture svih novopripravljenih derivata benzoksazola potvrđene su 1H- i 13C-NMR spektroskopijom.
Abstract (english)
This work describes the synthesis of new benzoxazole derivatives and their structural characterization by 1H- and 13C-NMR spectroscopy. The reaction of 4-hydroxybenzaldehyde and the corresponding alkylating reagents prepared O-alkylated benzaldehydes (1-6) as precursors which were then converted into derivatives of Schiff bases (7-19) with variously substituted ortho-aminophenols. Oxidative cyclization of Schiff bases benzoxazole derivatives (20-32) were synthesized. Microwave-assisted O-propargylation of 4-(5-methoxybenzo[d] oxazol-2-yl)phenol (32) with propargyl bromide using potassium carbonate as a base synthesized 5-methoxy-2-(4-(prop-2)-in-1-yloxy)phenyl)benzo[d]oxazole (33) which was then converted to 1,2,3-triazole benzoxazole derivatives (37-39) by the click reaction of 1,3-dipolar cycloaddition catalyzed by copper (I) iodide with previously obtained azides (34-36). The structures of all newly prepared benzoxazole derivatives were confirmed by 1H- and 13C-NMR spectroscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:364276
ProjectNumber: IP-2018-01-4682
Title: Novi spojevi temeljeni na bioizosterima purina za ispitivanje njihovih antitumorskih i antipatogenih djelovanja
Acronym: PurBioCaPa
Leader: Silvana Raić-Malić
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
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Created on2023-04-04 07:31:12