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undergraduate thesis
Uloga površinski aktivnih tvari u farmaceutskim formulacijama
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. urn:nbn:hr:149:014288
Keleković, Valentina
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Keleković, V. (2021). Uloga površinski aktivnih tvari u farmaceutskim formulacijama (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:014288

Keleković, Valentina. "Uloga površinski aktivnih tvari u farmaceutskim formulacijama." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:014288

Keleković, Valentina. "Uloga površinski aktivnih tvari u farmaceutskim formulacijama." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:014288

Keleković, V. (2021). 'Uloga površinski aktivnih tvari u farmaceutskim formulacijama', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:014288

Keleković V. Uloga površinski aktivnih tvari u farmaceutskim formulacijama [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2021 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:014288

V. Keleković, "Uloga površinski aktivnih tvari u farmaceutskim formulacijama", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:149:014288

Metadata
TitleUloga površinski aktivnih tvari u farmaceutskim formulacijama
Title (english)The role of surfactants in pharmaceutical formulations
AuthorValentina Keleković
MentorKrunoslav Žižek (mentor)
Committee memberKrunoslav Žižek (predsjednik povjerenstva)
Committee memberJuraj Šipušić (član povjerenstva)
Committee memberDragana Vuk (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2021-09-24, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Ovaj rad je sažet pregled značaja i uloge površinski aktivnih tvari u farmaceutskim pripravcima. Površinski aktivne tvari su amfifilne molekule koje posjeduju hidrofilni i hidrofobni dio. Zbog svoje strukture pokazuju posebna fenomenološka svojstva u vodenim otopinama: adsorpcija na granici faza i molekulsko samoudruživanje (micele, vezikule i tekući kristali). Takva svojstva su od velike važnosti u farmaceutskoj industriji, posebno kod istraživanja poboljšanja djelotvornosti lijeka. Za bolju apsorpciju djelatne tvari, a time i za povećanu bioraspoloživost i bolji ukupan farmakoterapijski učinak lijeka, djelatne tvari moraju biti dobro topljive u vodenom mediju te imati dobru propusnost kroz crijevnu membranu s ciljem ulaska u sistemsku cirkulaciju. Primjenjuju se kao nosači lijeka ili sustava za ciljanu isporuku. Postižu željenu koncentraciju lijeka na ciljanom mjestu u tijelu, a također štite tijelo od neželjenih nuspojava. Postoje različite vrste i oblici površinski aktivnih tvari. Ključno je razumijevanje njihovog faznog ponašanja za učinkovitu primjenu u terapijskim sustavima.
Abstract (english)
This thesis is a concise overview of the importance and the role of surfactants in pharmaceutical formulations. Surfactants are amphiphilic molecules that own a hydrophilic and a hydrophobic part. Due to their structure, they show special phenomenological properties in aqueous solutions: phase boundary adsorption and molecular self-aggregation (micelles, vesicles and liquid crystals). This properties are of great interest in pharmaceutical industy, especially at the research of drug efficiency enhancement. For better drug absorption, and therewith for increased bioavailability and better overall pharmacotherapeutic drug performance, drugs have to be well-soluble in an aqueous medium and to own good permeability through the intestinal membrane in order to enter the systemic circulation. They are used as drug carriers or targeted drug delivery systems. They achieve the desired concentration of the drug at the target site in the body, and also protect the body from unwanted side effects. There are different types and forms od surfactants. Understanding the phase behavior is crucial for their effective application in therapeutic systems.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:014288
Study programmeTitle: Chemical Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2021-09-24
Terms of useLicence In copyright icon
Created on2023-04-05 10:35:36