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master's thesis
Razvoj matematičkog modela sinteze ATP-a u kaskadnoj reakciji
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. urn:nbn:hr:149:787891
Plačko, Wanda
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Plačko, W. (2021). Razvoj matematičkog modela sinteze ATP-a u kaskadnoj reakciji (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:787891

Plačko, Wanda. "Razvoj matematičkog modela sinteze ATP-a u kaskadnoj reakciji." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:787891

Plačko, Wanda. "Razvoj matematičkog modela sinteze ATP-a u kaskadnoj reakciji." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:787891

Plačko, W. (2021). 'Razvoj matematičkog modela sinteze ATP-a u kaskadnoj reakciji', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 27 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:787891

Plačko W. Razvoj matematičkog modela sinteze ATP-a u kaskadnoj reakciji [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2021 [cited 2024 November 27] Available at: https://urn.nsk.hr/urn:nbn:hr:149:787891

W. Plačko, "Razvoj matematičkog modela sinteze ATP-a u kaskadnoj reakciji", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:149:787891

Metadata
TitleRazvoj matematičkog modela sinteze ATP-a u kaskadnoj reakciji
Title (english)Mathematical model development for ATP synthesis in a cascade reaction
AuthorWanda Plačko
MentorMartina Sudar (mentor)
Committee memberMartina Sudar (predsjednik povjerenstva)
Committee memberZvjezdana Findrik Blažević (član povjerenstva)
Committee memberDajana Kučić Grgić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2021-01-28, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Enzimske kaskadne reakcije predstavljaju obećavajući način sinteze tvari zbog većih iskorištenja procesa i smanjenja potrebe za dodavanjem drugih komponenti u proces te za pročišćavanjem produkata reakcije. Matematički modeli mogu dati dobar i brzi uvid u ovakve procese bez potrebe za provođenjem prevelikog broja eksperimenata. U ovom radu je razvijen matematički model sinteze ATP-a u kaskadnoj reakciji te su provedene simulacije pri različitim koncentracijama adenozina i magnezija. Time su dobiveni uvjeti pri kojima je moguće postići najveću koncentraciju ATP-a. Također je korištenjem razvijenog modela procijenjena osjetljivost kinetičkih parametara svake pojedinačne reakcije u ovom kaskadnom procesu. Prema dobivenim rezultatima može se zaključiti da parametri napredne reakcije katalizirane enzimom PPK2-I najviše utječu na ishod kaskadne reakcije.
Abstract (english)
Enzymatic cascade reactions are a promising way to synthesize substances due to the higher yield and the reduction of the need to add other components to the process and to purify the reaction products. Mathematical models can give a good and quick insight into such processes without the need to conduct too many experiments. A mathematical model of ATP synthesis in a cascade reaction was developed according to the obtained experimental data and simulations of the cascade reaction at different concentrations of adenosine and magnesium were performed. In that way conditions under which it is possible to achieve the highest concentration of ATP were estimated. Parameter sensitivity of each reaction in the cascade was estimated by simulations using the mathematical model. According to the obtained results it can be concluded that parameters in the forward reaction catalyzed by the enzyme PPK2-I have the highest effect on the outcome of the cascade reaction.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:787891
Study programmeTitle: Environmental Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka ekoinženjerstva (magistar/magistra inženjer/inženjerka ekoinženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-04-05 11:59:45