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undergraduate thesis
Ujednačenost sadržaja djelatne tvari u granulama
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. urn:nbn:hr:149:922048
Kopunić, Tamara
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Kopunić, T. (2021). Ujednačenost sadržaja djelatne tvari u granulama (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:922048

Kopunić, Tamara. "Ujednačenost sadržaja djelatne tvari u granulama." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:922048

Kopunić, Tamara. "Ujednačenost sadržaja djelatne tvari u granulama." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:922048

Kopunić, T. (2021). 'Ujednačenost sadržaja djelatne tvari u granulama', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 17 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:922048

Kopunić T. Ujednačenost sadržaja djelatne tvari u granulama [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2021 [cited 2024 November 17] Available at: https://urn.nsk.hr/urn:nbn:hr:149:922048

T. Kopunić, "Ujednačenost sadržaja djelatne tvari u granulama", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:149:922048

Metadata
TitleUjednačenost sadržaja djelatne tvari u granulama
Title (english)Drug content uniformity in granules
AuthorTamara Kopunić
MentorKrunoslav Žižek (mentor)
Committee memberKrunoslav Žižek (predsjednik povjerenstva)
Committee memberDragana Mutavdžić Pavlović (član povjerenstva)
Committee memberPetar Kassal (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2021-09-23, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
U formulaciji farmaceutskog pripravka nastoji se osigurati izvrsna ujednačenost sadržaja djelatne tvari u dozirnim jedinicama za dostavu lijeka, a time nužno i jednak sadržaj djelatne tvari u svim granulama neovisno o njihovoj veličini. U ovom istraživanju, nastoji se utvrditi sadržaj lurasidon-hidroklorida u granulama različitih veličina (veličinskih razreda/intervala). U pripravi granula različitih veličina koristi se procesna tehnologija in-situ granuliranja taljenjem u fluidiziranom sloju. Sadržaj djelatne tvari u granulama različitih veličina određen je UV/Vis spektrofotometrijom. Ovo istraživanje ukazuje na neujednačenost sadržaja djelatne tvari u granulama različitih veličina odnosno na intra- i intervarijabilnost sadržaja u granulama i time objašnjava značajno odstupanje od ciljanog sadržaja djelatne tvari u raspadljivim tabletama.
Abstract (english)
In pharmaceutical formulation there is an effort to provide an excellent drug content uniformity in dosage units for drug delivery, and therewith essentially and equal drug content in all granules irrespective of their sizes. In this research, there is an effort to determine the content of lurasidone hydrochloride in granules of different sizes (size classes/intervals). Process technology of in-situ fluidized bed melt granulation is used to prepare granules of different sizes. Drug content in granules of different sizes was detected by UV/Vis spectrophotometry. This research indicate to the non-uniformity of drug content in granules of different sizes that is to the intra- and intervariability of content in granules and therewith it explains significant deviation from targeted drug content in disintegrating tablets.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:922048
Study programmeTitle: Environmental Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2021-09-23
Terms of useLicence In copyright icon
Created on2023-04-05 12:30:51