prikaz prve stranice dokumenta Sinteza novih derivata benzotiazola s potencijalnim antitumorskim djelovanjem
Embargo period 2025-10-01
undergraduate thesis
Sinteza novih derivata benzotiazola s potencijalnim antitumorskim djelovanjem
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. urn:nbn:hr:149:847052
Mamić, Antonija
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Mamić, A. (2021). Sinteza novih derivata benzotiazola s potencijalnim antitumorskim djelovanjem (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:847052

Mamić, Antonija. "Sinteza novih derivata benzotiazola s potencijalnim antitumorskim djelovanjem." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:847052

Mamić, Antonija. "Sinteza novih derivata benzotiazola s potencijalnim antitumorskim djelovanjem." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:847052

Mamić, A. (2021). 'Sinteza novih derivata benzotiazola s potencijalnim antitumorskim djelovanjem', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:847052

Mamić A. Sinteza novih derivata benzotiazola s potencijalnim antitumorskim djelovanjem [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2021 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:149:847052

A. Mamić, "Sinteza novih derivata benzotiazola s potencijalnim antitumorskim djelovanjem", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:149:847052

Metadata
TitleSinteza novih derivata benzotiazola s potencijalnim antitumorskim djelovanjem
Title (english)Synthesis of novel benzothiazole derivatives with antitumoral potential
AuthorAntonija Mamić
MentorTatjana Gazivoda Kraljević (mentor)
Committee memberTatjana Gazivoda Kraljević (predsjednik povjerenstva)
Committee memberSilvija Maračić (član povjerenstva)
Committee memberDragana Mutavdžić Pavlović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2021-09-17, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U ovom radu je opisana sinteza novih 1,2,3-triazolnih derivata benzotiazola te njihova strukturna karakterizacija 1H- i 13C-NMR spektroskopijom. Mikrovalovima potpomognutom SN2 reakcijom 2-hidroksibenzaldehida i propargil-bromida uz K2CO3 kao bazu pripravljen je 2-(prop-2-in-1-iloksi)benzaldehid (1). Propargilirani derivat benzotiazola (2) priređen je ciklizacijom 2-O-propargilbenzaldehida (1) i ortho-aminotiofenola u dimetilformamidu uz oksidacijsko sredstvo Na2S2O5. Ciljani 1,2,3-triazolni derivati benzotiazola (3 – 14) sintetizirani su mehanokemijskim reakcijama Huisgenovom 1,3-dipolarnom cikloadicijom 2-(2-(prop-2-in-1-iloksi)fenil)benzo[d]tiazola (2) i odgovarajućih aromatskih azida uz bakrov(II) acetat kao katalizator. Strukture svih novopriređenih spojeva potvrđene su 1H- i 13C-NMR spektroskopijom.
Abstract (english)
This paper describes the synthesis of new 1,2,3-triazolyl benzothiazole derivatives and their structural characterization by 1H- and 13C-NMR spectroscopy. Microwave-assisted SN2 reaction of 2-hydroxybenzaldehyde and propargyl bromide with K2CO3 as a base 2-(prop-2-yn-1-yloxy)benzaldehyde (1) was prepared. A propargylated benzothiazole derivative (2) was prepared by cyclization of 2-O-propargylbenzaldehyde (1) and ortho-aminothiophenol in dimethylformamide using Na2S2O5 as oxidizing agent. Target 1,2,3-triazolyl benzothiazole derivatives (3 - 14) were synthesized by mechanochemical reactions by Huisgen 1,3-dipolar cycloaddition of 2-(2-(prop-2-yn-1-yloxy)phenyl)benzo[d]thiazole (2) and the corresponding aromatic azides with copper (II) acetate as catalyst. The structures of all newly prepared compounds were confirmed by 1H- and 13C-NMR spectroscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:847052
ProjectNumber: IP-2018-01-4682
Title: Novi spojevi temeljeni na bioizosterima purina za ispitivanje njihovih antitumorskih i antipatogenih djelovanja
Acronym: PurBioCaPa
Leader: Silvana Raić-Malić
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Materials Science and Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
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Created on2023-04-07 08:23:01