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undergraduate thesis
In vitro oslobađanje djelatne tvari iz transdermalnih pripravaka
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. urn:nbn:hr:149:733845
Meštrović, Magda
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Meštrović, M. (2021). In vitro oslobađanje djelatne tvari iz transdermalnih pripravaka (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:733845

Meštrović, Magda. "In vitro oslobađanje djelatne tvari iz transdermalnih pripravaka." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:733845

Meštrović, Magda. "In vitro oslobađanje djelatne tvari iz transdermalnih pripravaka." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:733845

Meštrović, M. (2021). 'In vitro oslobađanje djelatne tvari iz transdermalnih pripravaka', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:733845

Meštrović M. In vitro oslobađanje djelatne tvari iz transdermalnih pripravaka [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2021 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:149:733845

M. Meštrović, "In vitro oslobađanje djelatne tvari iz transdermalnih pripravaka", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:149:733845

Metadata
TitleIn vitro oslobađanje djelatne tvari iz transdermalnih pripravaka
Title (english)In vitro release of the active ingredient from transdermal system
AuthorMagda Meštrović
MentorGordana Matijašić (mentor)
Committee memberGordana Matijašić (predsjednik povjerenstva)
Committee memberKrunoslav Žižek (član povjerenstva)
Committee memberJuraj Šipušić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2021-07-09, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Cilj ovoga rada je provesti in vitro ispitivanje oslobađanja celekoksiba iz transdermalnog pripravka. Ispitivanje se provodi upotrebom Franzovih difuzijskih ćelija, a prvi je zadatak savladavanje metode in vitro ispitivanja. Dobiveni podaci se obrađuju kako bi se proveo odabir odgovarajućeg kinetičkog modela kojim bi se potencijalno mogao opisati prijelaz djelatne tvari iz transdermalnog pripravka u sistemsku cirkulaciju. Za analizu kinetičkih modela koristi se dodatak za Microsoft Excel program, DDSolver. Prema dobivenim podacima, oslobađanje celekoksiba iz transdermalnog pripravka opisuje se Korsmeyer-Peppasovim kinetičkim modelom. Taj model definiran je dvama parametrima: konstantom brzine oslobađanja djelatne tvari (kr) i eksponentom difuzije (n) koji za ovaj model poprima vrijednosti u intervalu od 0,5 do 1. U tom slučaju, mehanizam oslobađanja djelatne tvari opisuje se difuzijom koja odstupa od Fickova zakona, tzv. anomalnom difuzijom.
Abstract (english)
The aim of this work is to study the in vitro release of celecoxib from the transdermal system. For this purpose Franz diffusion cells are used and it is important to master the in vitro release method. The results are analyzed to determine which kinetic model is appropriate for the observed drug release from the transdermal system into a systemic circulation. With the intention of analyzing kinetic models, Microsoft Excel's DDSolver program is used. According to the results, the Korsmeyer-Peppas model describes the release of celecoxib from the transdermal system. This model is defined by two parameters: release constant (kr) and diffusion exponent (n), which is in the range of 0.5 and 1. In this case, the release mechanism is described with anomalous diffusion. Thus, Fick’s diffusion law cannot describe the release mechanism of celecoxib.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:733845
Study programmeTitle: Chemical Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2023-04-11 07:21:12