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master's thesis
Utjecaj procesnih parametara na granulometrijska svojstva djelatne tvari
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. urn:nbn:hr:149:072884
Pastuović, Domagoj
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Pastuović, D. (2021). Utjecaj procesnih parametara na granulometrijska svojstva djelatne tvari (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:072884

Pastuović, Domagoj. "Utjecaj procesnih parametara na granulometrijska svojstva djelatne tvari." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:072884

Pastuović, Domagoj. "Utjecaj procesnih parametara na granulometrijska svojstva djelatne tvari." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:072884

Pastuović, D. (2021). 'Utjecaj procesnih parametara na granulometrijska svojstva djelatne tvari', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:072884

Pastuović D. Utjecaj procesnih parametara na granulometrijska svojstva djelatne tvari [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2021 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:072884

D. Pastuović, "Utjecaj procesnih parametara na granulometrijska svojstva djelatne tvari", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:149:072884

Metadata
TitleUtjecaj procesnih parametara na granulometrijska svojstva djelatne tvari
Title (english)Influence of process parameters on granulometric properties of active pharmaceutical ingredient
AuthorDomagoj Pastuović
MentorJasna Prlić Kardum (mentor)
MentorFranjo Jović (komentor)
Committee memberJasna Prlić Kardum (predsjednik povjerenstva)
Committee memberFranjo Jović (član povjerenstva)
Committee memberLidija Furač (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2021-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Kako bi se dobio proizvod zadovoljavajuće kvalitete te uspješno proveo proces kristalizacije, potrebno je odabirati odgovarajući sustav i optimalne procesne uvjete. Promjenom različitih procesnih parametara, moguće je utjecati na granulometrijska svojstva djelatne tvari, poput veličine kristala, raspodjele veličina kristala i oblika dobivenih kristala. U ovom diplomskom radu prikazani su rezultati istraživanja utjecaja različitih procesnih parametara kako bi se dobio proizvod željenih granulometrijskih karakteristika. Određena je topljivost djelatne tvari u sustavu etanol-voda. Također, istražen je utjecaj načina hlađenja otopine (profili i brzina hlađenja), na granulometrijska svojstva nastalih kristala. Istražen je i utjecaj dodatka cjepiva u sustav tijekom šaržne kristalizacije hlađenjem, a dobivenim kristalima određena je filtrabilnost pod tlakom. Ispitana su ispitana reološka svojstva prašaka i određena je raspodjela veličina kristala jer je to od iznimne važnosti prilikom tabletiranja.
Abstract (english)
In order to obtain a product of satisfactory quality and successfully carry out the crystallization process, it is necessary to select the appropriate system and optimal process conditions. By changing different process parameters, it is possible to influence the granulometric properties of the active substance, such as the crystal size, the crystal size distribution and the shape of the obtained crystals. This thesis presents the results of research on the influence of different process parameters in order to obtain the product of the desired granulometric characteristics. The solubility of the active substance in the ethanol-water system was determined. Also, the influence of the solution cooling method (profiles and cooling rate) on the granulometric properties of the formed crystals were explored. The influence of the seed addition to the system during batch crystallization by cooling were also explored, and the obtained crystals were determined to be filterable under pressure. The rheological properties of the powders were examined and the distribution of crystal sizes was determined because it is extremely important during tableting.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:072884
Study programmeTitle: Chemical Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2023-04-11 08:20:53