Organic solvents are used for the extraction and separation of biocomponents, which brings major environmental problems. To reduce this problem, numerous studies have been launched to find renewable green solvents. Deep Eutectic Solvents-DES and Natural Deep Eutectic Solvents-NADES have proven to be good alternatives for organic solvents and ionic liquids. These solvents are characterized by non-toxicity, non-flammability, biodegradability and low price. Polyphenols are compounds that have good influence on human health, great morphological and physiological significance. These are natural antioxidants that prevent all kinds of diseases, have a positive effect on cardiovascular difficulties and slow down aging. In this paper, it was studied the suitability for the extraction of polyphenols from the plantain leaves (lat.Plantago major), of DES and NADES in relation to conventional solvents. 22 different solvents were prepared and characterized. The results of polyphenol extraction, density and pH value are presented. The accent is on solvents which consist of two components: lactic acid and glycerol (LaGly) with different content of water. After extraction, the amount of polyphenols in the isolated extract was analyzed. The study showed that the most suitable solvent for extraction polyphenols from the plantain leaves was LaGly 2:1 with 10% water.