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master's thesis
Utjecaj antiotapala na granulometrijska svojstva kristala
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. urn:nbn:hr:149:247372
Prlić, Domagoj
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Prlić, D. (2021). Utjecaj antiotapala na granulometrijska svojstva kristala (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:247372

Prlić, Domagoj. "Utjecaj antiotapala na granulometrijska svojstva kristala." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:247372

Prlić, Domagoj. "Utjecaj antiotapala na granulometrijska svojstva kristala." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:247372

Prlić, D. (2021). 'Utjecaj antiotapala na granulometrijska svojstva kristala', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:247372

Prlić D. Utjecaj antiotapala na granulometrijska svojstva kristala [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2021 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:247372

D. Prlić, "Utjecaj antiotapala na granulometrijska svojstva kristala", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:149:247372

Metadata
TitleUtjecaj antiotapala na granulometrijska svojstva kristala
Title (english)Influence of antisolvents on granulometric properties of crystals
AuthorDomagoj Prlić
MentorAleksandra Sander (mentor)
Committee memberAleksandra Sander (predsjednik povjerenstva)
Committee memberJasna Prlić Kardum (član povjerenstva)
Committee memberLidija Furač (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2021-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Kristalizacija je jedna od najvažnijih procesa farmaceutske industrije. Odabir procesnih uvjeta značajno utječe na veličinu, oblik te samu čistoću kristala. Oblik i veličina kristala od presudne su važnosti za formulaciju čvrstih oblika lijeka. Moguće strukturne transformacije kristala izbjegavaju se ispitivanjem i određivanjem termodinamički najstabilnije forme. U ovom radu provedena je kristalizacija uz dodatak antiotapala, a ispitivana djelatna tvar bila je je Omeprazol koji je predstavnik naprednih lijekova za liječenje peptidnih bolesti. Dodatkom različitih antiotapala te za različite brzine dodatka antiotapala uz održavanje konstantne temperature dobiveni su kristali različitih granulometrijskih karakteristika. Za odabrane procesne uvjete ispitan je utjecaj kubnog profila hlađenja na iskorištenje kristalizacije. Dobivenim kristalima određena je raspodjela veličina kristala, pojavni oblik i unutarnja struktura te toplinska karakterizacija.
Abstract (english)
Crystallization is one of the most important processes in the pharmaceutical industry. The choice of process conditions significantly affects the size, shape and purity of the crystal. The shape and size of the crystals are crucial for the formulation of solid drug forms. Possible structural transformations of crystals are avoided by examining and determining the thermodynamically most stable form. In this work, crystallization with the addition of anti-solvents was performed, and the active substance tested was Omeprazole, which is a representative of advanced drugs for the treatment of peptide diseases. Crystals of different granulometric characteristics were obtained by adding different anti-solvents and for different rates of addition of anti-solvents while maintaining a constant temperature. For selected process conditions, the influence of the cubic cooling profile on the crystallization yield was examined. The obtained crystals were used to determine the crystal size distribution, appearance and internal structure, and thermal characterization.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:247372
Study programmeTitle: Materials Science and Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-04-11 10:05:30