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master's thesis
Priprema uzoraka aktivnog mulja za kromatografsku analizu ksenobiotika
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. urn:nbn:hr:149:081536
Hlevnjak, Ivana
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Hlevnjak, I. (2021). Priprema uzoraka aktivnog mulja za kromatografsku analizu ksenobiotika (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:081536

Hlevnjak, Ivana. "Priprema uzoraka aktivnog mulja za kromatografsku analizu ksenobiotika." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:081536

Hlevnjak, Ivana. "Priprema uzoraka aktivnog mulja za kromatografsku analizu ksenobiotika." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:081536

Hlevnjak, I. (2021). 'Priprema uzoraka aktivnog mulja za kromatografsku analizu ksenobiotika', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:081536

Hlevnjak I. Priprema uzoraka aktivnog mulja za kromatografsku analizu ksenobiotika [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2021 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:081536

I. Hlevnjak, "Priprema uzoraka aktivnog mulja za kromatografsku analizu ksenobiotika", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:149:081536

Metadata
TitlePriprema uzoraka aktivnog mulja za kromatografsku analizu ksenobiotika
Title (english)Sample preparation of activate sludge for chromatographic analysis of xenobiotics
AuthorIvana Hlevnjak
MentorDanijela Ašperger (mentor)
Committee memberDanijela Ašperger (predsjednik povjerenstva)
Committee memberMartina Biošić (član povjerenstva)
Committee memberDragana Vuk (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2021-09-24, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Farmaceutski ksenobiotici vrsta su onečišćujućih tvari široko rasprostranjenih u sustavima za obradu otpadnih voda. Većina njih nalazi se u aktivnom mulju dobivenom u sekundardnom procesu obrade otpadnih voda. Aktivni mulj veoma je složena matica koja zahtjeva pripremu kako bi se ekstrahirali analiti i uklonile interferencije. U ovome radu za pripremu uzoraka aktivnog mulja koristila se metoda ekstrakcije raspršenjem matice uzorka kroz čvrstu fazu (MSPD). Određivanje ksenobiotika provedeno je tekućinskom kromatografijom visoke djelotvornosti s detektorom s nizom dioda (HPLC-DAD). Analizirano je sedam ksenobiotika, uključujući antibiotike (cefdinir i nitrofurantoin), antihelmintike (albendazol, febantel i prazikvantel), antiemetik (metoklopramid) i antimalarik (hidroksiklorokin). Neki od parametara MSPD ekstrakcije koji su optimizirani su vrsta sorbensa, omjer mase aktivnog mulja i sorbensa, koncentracija standardne otopine i ekstrakcijsko otapalo. Najbolji rezultati su postignuti korištenjem ljuski jajeta s omjerom mase aktivnog mulja i ljuski jajeta (1:7) i ekstrahiranjem s 5 mL smjese otapala metanol:voda (50:50).
Abstract (english)
Pharmaceutical xenobiotics are a type of pollutant widely used in wastewater treatment systems. Most of them are found in activated sludge obtained in the secondary process of wastewater treatment. Activated sludge is a very complex matrix that requires preparation to extract analytes and remove interference. In this study, the method of extraction by matrix solid-phase dispersion (MSPD) was used for the preparation of activated sludge samples. Determination of xenobiotics was performed by high performance liquid chromatography with a diode array detector (HPLC-DAD). Seven xenobiotics were analyzed, including antibiotics (cefdinir and nitrofurantoin), anthelmintics (albendazole, febantel, and praziquantel), antiemetics (metoclopramide), and antimalarials (hydroxychloroquine). Some of the MSPD extraction parameters that have been optimized are sorbent type, activated sludge to sorbent mass ratio, standard solution concentration, and extraction solvent. The best results were obtained using egg shells with a ratio of activated sludge to egg shells (1:7) and extraction with 5 mL of a solvent mixture of methanol:water (50:50).
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:081536
Study programmeTitle: Chemical Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
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Created on2023-04-17 12:15:26