prikaz prve stranice dokumenta Evaluation of water matrix effect on degradation of pharmaceuticals and determination of degradation mechanism
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master's thesis
Evaluation of water matrix effect on degradation of pharmaceuticals and determination of degradation mechanism
Zagreb, Split: University of Zagreb, Faculty of Chemical Engineering and Technology, 2021. urn:nbn:hr:149:140589
Samzadeh, Amin
University of Zagreb
Faculty of Chemical Engineering and Technology
University of Split
Faculty of Chemistry and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Samzadeh, A. (2021). Evaluation of water matrix effect on degradation of pharmaceuticals and determination of degradation mechanism (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; Split: University of Split, Faculty of Chemistry and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:140589

Samzadeh, Amin. "Evaluation of water matrix effect on degradation of pharmaceuticals and determination of degradation mechanism." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology; University of Split, Faculty of Chemistry and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:140589

Samzadeh, Amin. "Evaluation of water matrix effect on degradation of pharmaceuticals and determination of degradation mechanism." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology; University of Split, Faculty of Chemistry and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:149:140589

Samzadeh, A. (2021). 'Evaluation of water matrix effect on degradation of pharmaceuticals and determination of degradation mechanism', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology; University of Split, Faculty of Chemistry and Technology, accessed 17 February 2025, https://urn.nsk.hr/urn:nbn:hr:149:140589

Samzadeh A. Evaluation of water matrix effect on degradation of pharmaceuticals and determination of degradation mechanism [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; Split: University of Split, Faculty of Chemistry and Technology; 2021 [cited 2025 February 17] Available at: https://urn.nsk.hr/urn:nbn:hr:149:140589

A. Samzadeh, "Evaluation of water matrix effect on degradation of pharmaceuticals and determination of degradation mechanism", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb; University of Split, Faculty of Chemistry and Technology, Split, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:149:140589

Metadata
TitleEvaluation of water matrix effect on degradation of pharmaceuticals and determination of degradation mechanism
Title (croatian)Procjena utjecaja vodene matrice na razgradnju farmaceutika i određivanje mehanizma razgradnje
AuthorAmin Samzadeh
MentorTomislav Bolanča (mentor)
Committee memberTomislav Bolanča (predsjednik povjerenstva)
Committee memberHrvoje Kušić (član povjerenstva)
Committee memberAna Lončarić Božić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
GranterUniversity of Split
Faculty of Chemistry and Technology
Split
Defense date and country2021-06-25, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
According to the 3rd EU Watch List under the Water Framework Directive, a list of substances was suggested as good candidates for the next watchlist. In this study two pharmaceuticals from this list were chosen, Carbamazepine (CBZ) and Ibuprofen (IBP), two important and widely used recalcitrant pharmaceuticals found in water. The aim of this study is to evaluate the influence of several water matrix factors on the degradation of CBZ and IBP, with three different advanced oxidation processes (AOPs). To the best of our knowledge so far, there has been no research comparing UV-C, ultrasound (US) and microwave (MW) based processes under different operational parameters (oxidant dosage, pH, humic acid, nitrite ion, nitrate ion, chloride ion, phosphate ion and sulfate ion). Each of these factors depend on the degradation process had synergistic or inhibitory effect on degradation rate of studied pharmaceuticals. The used Taguchi method had great and significant results and indicated the effect of studied factors on degradation processes that, in most cases, were in agreement with previous literature findings, as well as required fewer experiments, time, and costs. Water matrix constituents had a significant impact on the degradation efficiency. Furthermore, the biodegradability of CBZ and IBP and degradation products of CBZ through UV-C based processes were investigated.
Abstract (croatian)
Prema 3. popisu prioritetnih tvari prema Okvirnoj direktivi o vodama EU, popis tvari koje treba pratiti predložen je kao dobar kandidat za sljedeći popis prioritetnih tvari. U ovom radu odabrana su dva farmaceutika s ovog popisa, karbamazepin (CBZ) i ibuprofen (IBP), dva važna i široko korištena rekalcitratna farmaceutika pronađena u vodi. Cilj ovog istraživanja je procijeniti utjecaj nekoliko čimbenika vodene matrice na razgradnju CBZ i IBP, s tri različita napredna oksidacijska procesa (AOP). Koliko nam je poznato, do sada nije bilo istraživanja koja bi uspoređivala procese temeljene na UV-C, ultrazvuku (US) i mikrovalovima (MW) pod različitim radnim parametrima (doza oksidansa, pH, huminska kiselina, nitritni ion, nitratni ion, klorid ion, fosfatni ion i sulfatni ion). Svaki od ovih čimbenika, ovisno o procesu razgradnje, imao je sinergistički ili inhibitorni učinak na brzinu razgradnje ispitivanih farmaceutika. Korištena Taguchi metoda dala je izvrsne i značajne rezultate te je ukazala na utjecaj proučavanih čimbenika na procese razgradnje koji su u većini slučajeva bili u skladu s dosadašnjim literaturnim nalazima, te su zahtijevali manje eksperimenata, vremena i troškova. Sastojci vodene matrice imali su značajan utjecaj na učinkovitost razgradnje. Nadalje, ispitana je biorazgradivost CBZ-a i IBP-a i produkti razgradnje CBZ-a putem UV-C procesa.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:149:140589
Study programmeTitle: Chemical and environmental technology - graduate - university
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2022-06-30
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Created on2023-04-21 13:32:40