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undergraduate thesis
Sinteza amino-supstituiranih derivata benzotiazola
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. urn:nbn:hr:149:644027
Mijić, Helena
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Mijić, H. (2019). Sinteza amino-supstituiranih derivata benzotiazola (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:644027

Mijić, Helena. "Sinteza amino-supstituiranih derivata benzotiazola." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:644027

Mijić, Helena. "Sinteza amino-supstituiranih derivata benzotiazola." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:644027

Mijić, H. (2019). 'Sinteza amino-supstituiranih derivata benzotiazola', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:644027

Mijić H. Sinteza amino-supstituiranih derivata benzotiazola [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2019 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:644027

H. Mijić, "Sinteza amino-supstituiranih derivata benzotiazola", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:149:644027

Metadata
TitleSinteza amino-supstituiranih derivata benzotiazola
Title (english)Synthesis of amino-substituted benzothiazoles derivatives
AuthorHelena Mijić
MentorSilvana Raić-Malić (mentor)
Committee memberSilvana Raić-Malić (predsjednik povjerenstva)
Committee memberSilvija Maračić (član povjerenstva)
Committee memberMirjana Novak Stankov (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2019-09-18, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Cilj ovog rada bila je sinteza novih 2-amino-supstituiranih benzotiazola 5-7, te 6-amino-supstituiranih benzotiazola 13-17. Za pripravu ciljnih spojeva korištene su klasične metode organske sinteze. Sinteza 2-amino supstituiranih derivata benzotiazola provedena je reduktivnom aminacijom, kojom je dobiven spoj N-(4-(2-fenil-2-oksoetoksi)benzil)benzotiazol-2-amin 5, dok se sintezi 6-amino-susptituiranih derivata pristupilo na dva načina, reakcijom nukleofilne supstitucije i Buchwald-Hartwig-ovom reakcijom. Prvim sintetskim putem, nukleofilnom supstitucijom iz kloriranog derivata 12, nisu dobiveni ciljni spojevi 13 i 14. Provedbom Buchwald-Hartwig-ove reakcije, iz prekursora 11, uspješno je dobiven spoj 6-fenilamino-2-(4-hidroksifenil)benzotiazol 15, dok sinteza spojeva 16 i 17 nije bila uspješna. Strukture svih sintetiziranih spojeva potvrđene su 1H i 13C NMR spektroskopijom.
Abstract (english)
The aim of this study was the synthesis of novel 2-amino-substituted benzothiazoles 5-7 and 6-amino-substituted benzothiazoles 13-17. For the synthesis of target compounds classical methods of organic synthesis were used. Synthesis of 2-amino-substituted benzothiazole derivatives was carried out by reductive amination to give N-4-(2-phenyl-2-oxoethoxy)benzyl)benzothiazole-2-amine 5, while the synthesis of 6-amino-substituted derivatives was carried out by two syntetic pathways, by nucleophilic substitution reaction and Buchwald-Hartwig reaction. The first synthetic route, by nucleophilic substitution from chlorinated derivative 12, did not yield the target compounds 13 and 14. Compound 6-phenylamino-2-(4-hydroxyphenyl)benzothiazole 15 was successfully synthesized by Buchwald-Hartwig reaction, from precursor 11 while the synthesis of compounds 16 and 17 was not successful. The structures of all the synthesized compounds were confirmed by 1H and 13C NMR spectroscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:644027
ProjectNumber: IP-2018-01-4682
Title: Novi spojevi temeljeni na bioizosterima purina za ispitivanje njihovih antitumorskih i antipatogenih djelovanja
Acronym: PurBioCaPa
Leader: Silvana Raić-Malić
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
File originBorn digital
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Created on2023-05-26 08:44:16