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undergraduate thesis
Određivanje fizikalno-kemijskih svojstava i in silico analiza odabranih amino-1,3-benzotiazina
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. urn:nbn:hr:149:697256
Penava, Ana
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Penava, A. (2019). Određivanje fizikalno-kemijskih svojstava i in silico analiza odabranih amino-1,3-benzotiazina (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:697256

Penava, Ana. "Određivanje fizikalno-kemijskih svojstava i in silico analiza odabranih amino-1,3-benzotiazina." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:697256

Penava, Ana. "Određivanje fizikalno-kemijskih svojstava i in silico analiza odabranih amino-1,3-benzotiazina." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:697256

Penava, A. (2019). 'Određivanje fizikalno-kemijskih svojstava i in silico analiza odabranih amino-1,3-benzotiazina', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 17 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:697256

Penava A. Određivanje fizikalno-kemijskih svojstava i in silico analiza odabranih amino-1,3-benzotiazina [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2019 [cited 2024 November 17] Available at: https://urn.nsk.hr/urn:nbn:hr:149:697256

A. Penava, "Određivanje fizikalno-kemijskih svojstava i in silico analiza odabranih amino-1,3-benzotiazina", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:149:697256

Metadata
TitleOdređivanje fizikalno-kemijskih svojstava i in silico analiza odabranih amino-1,3-benzotiazina
Title (english)Determination of physico-chemical properties and in silico analysis of the selected amino-1,3-benzothiazines
AuthorAna Penava
MentorIrena Škorić (mentor)
Committee memberIrena Škorić (predsjednik povjerenstva)
Committee memberDragana Vuk (član povjerenstva)
Committee memberLidija Furač (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2019-09-19, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Apsorpcija, distribucija, mehanizam i ekskrekcija lijekova ključni su parametri u istraživanju i razvoju lijekova koji određuju bioraspoloživost lijekova i njihov utjecaj na ljudski organizam. Potencijalna biološka aktivnost određenih spojeva može se ispitati in silico analizom. Lipofilnost je jedno od najvažnijih fizikalno-kemijskih svojstava lijekova jer opisuje odnos lijekova i njihovih bioloških, farmakokinetičkih i metaboličkih svojstava. Logaritamska vrijednost particijskog koeficijenta ispitivanog spoja pruža uvid u njegovu lipofilnost, koja opisuje raspodjelu ispitivanog spoja između organske i vodene faze. Logaritamska vrijednost particijskog koeficijenta odabranih 1,3-benzotiazina i amino-1,3-benzotiazina u ovom radu određivala se direktnom metodom, metodom protresanja tikvicom, te na temelju teorijskog proračuna. Na temelju rezultata dobivenih direktnom metodom, može se zaključiti da su određeni derivati 1,3-benzotiazina lipofilni te predstavljaju potencijalne kandidate za daljnja predklinička i klinička ispitivanja kojima se može utvrditi njihova biološka aktivnost.
Abstract (english)
Drug absorption, distribution, metabolism and excretion are key parameters in drug design and development that determine drug bioavailability and drug impact on human body. In silico analysis provides insight into potential drug candidate biological activity. Lipophilicity is one of the most important physicochemical property of a drug because it describes the relationship between drugs and their biological, pharmacokinetic and metabolic properties. Logarithmic value of partition coefficient of a test compound provides insight into its lipophilicity, which describes the distribution of the test compound between an organic and an aqueous phase. Logarithmic values of partition coefficient of selected 1,3-benzothiazines and amino-1,3-benzothiazines in this paper were determined by the direct method, the shake-flask method, and by theoretical calculation. Based on the results obtained by the direct method, it can be concluded that certain 1,3-benzothiazine derivatives are lipophilic and they can be included in further preclinical and clinical trials that can determine their biological activity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:697256
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2023-05-26 12:53:52