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undergraduate thesis
Sinteza i strukturna karakterizacija 2-aril-6-fluorbenztiazola
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. urn:nbn:hr:149:446445
Prenc, Sara
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Prenc, S. (2019). Sinteza i strukturna karakterizacija 2-aril-6-fluorbenztiazola (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:446445

Prenc, Sara. "Sinteza i strukturna karakterizacija 2-aril-6-fluorbenztiazola." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:446445

Prenc, Sara. "Sinteza i strukturna karakterizacija 2-aril-6-fluorbenztiazola." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:446445

Prenc, S. (2019). 'Sinteza i strukturna karakterizacija 2-aril-6-fluorbenztiazola', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:446445

Prenc S. Sinteza i strukturna karakterizacija 2-aril-6-fluorbenztiazola [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2019 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:446445

S. Prenc, "Sinteza i strukturna karakterizacija 2-aril-6-fluorbenztiazola", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:149:446445

Metadata
TitleSinteza i strukturna karakterizacija 2-aril-6-fluorbenztiazola
Title (english)Synthesis and structural characterization of 2-aryl-6-fluorobenzothiazole
AuthorSara Prenc
MentorTatjana Gazivoda Kraljević (mentor)
Committee memberTatjana Gazivoda Kraljević (predsjednik povjerenstva)
Committee memberDragana Mutavdžić Pavlović (član povjerenstva)
Committee memberLidija Furač (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2019-09-19, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U ovom radu opisana je sinteza novih derivata benztiazola i njihova strukturna karakterizacija 1H-NMR i FTIR spektroskopijom. Reakcijom 2-aminotiofenola (1) i 2-amino-5-fluorotiofenola (3) s 3-fluor-4-hidroksibenzaldehidom pripravljeni su 2-(4-hidroksi-3-fluorfenil)benztiazol (4) i 2-fluor-4-(6-fluorbenzo[d]tiazol-2-il)fenol (5) koji su potom mikrovalovima potpomognutim O-alkiliranjem prevedeni u odgovarajuće derivate benztiazola (6-10). Propargiliranjem benztiazolnih derivata (4 i 5) s propargil-bromidom uz natrijev hidrid kao bazu sintetizirani su O-propargilirani derivati benztiazola 12 i 13 koji klik reakcijom kataliziranom bakrom s N-azidoetilmorfolinom (14) nisu dali ciljane 1,2,3-triazolne derivate benztiazola. Strukture svih novopripravljenih spojeva potvrđene su 1H-NMR i FTIR spektroskopijom.
Abstract (english)
This paper describes the synthesis of new benzothiazole derivatives and their structural characterization by 1H-NMR and FTIR spectroscopy. 2-(4-hydroxy-3-fluorophenyl)benzothiazole (4) and 2-fluoro-4-(6-fluorobenzo[d]thiazol-2-yl)phenol (5) were prepared by reaction of 2-aminothiophenol (1) and 2-amino-5-fluorothiophenol (3) with 3-fluoro-4-hydroxybenzaldehyde, which were then converted under microwave irradiation into the corresponding benzothiazole derivatives (6-10). Propargylation of benztohiazole derivatives (4 and 5) with propargyl bromide using sodium hydride as a base gave O-propargylated benzothiazole derivatives 12 and 13, which didn't give by copper catalysed click reaction with ethylmorpholine azide (14) desired 1,2,3-triazole derivatives of benzothiazole 15 and 16. The structures of all newly prepared compounds were confirmed by 1H-NMR and FTIR spectroscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:446445
ProjectNumber: IP-2018-01-4682
Title: Novi spojevi temeljeni na bioizosterima purina za ispitivanje njihovih antitumorskih i antipatogenih djelovanja
Acronym: PurBioCaPa
Leader: Silvana Raić-Malić
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2023-05-28 15:45:10