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undergraduate thesis
Određivanje sadržaja lurasidon-hidroklorida u čvrstim disperzijama
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. urn:nbn:hr:149:292549
Sokač, Katarina
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Sokač, K. (2019). Određivanje sadržaja lurasidon-hidroklorida u čvrstim disperzijama (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:292549

Sokač, Katarina. "Određivanje sadržaja lurasidon-hidroklorida u čvrstim disperzijama." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:292549

Sokač, Katarina. "Određivanje sadržaja lurasidon-hidroklorida u čvrstim disperzijama." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:292549

Sokač, K. (2019). 'Određivanje sadržaja lurasidon-hidroklorida u čvrstim disperzijama', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:292549

Sokač K. Određivanje sadržaja lurasidon-hidroklorida u čvrstim disperzijama [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2019 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:149:292549

K. Sokač, "Određivanje sadržaja lurasidon-hidroklorida u čvrstim disperzijama", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:149:292549

Metadata
TitleOdređivanje sadržaja lurasidon-hidroklorida u čvrstim disperzijama
Title (english)Determination of lurasidone hydrochloride content in solid dispersions
AuthorKatarina Sokač
MentorKrunoslav Žižek (mentor)
Committee memberKrunoslav Žižek (predsjednik povjerenstva)
Committee memberMirela Leskovac (član povjerenstva)
Committee memberIrena Škorić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2019-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Lurasidon-hidroklorid je djelatna tvar izrazito male topljivosti u vodenom mediju što otežava njegovu primjenu u liječenju psihičkih poremećaja. S ciljem povećanja njegove topljivosti, metodom isparavanja otapala pripravljene su čvrste disperzije djelatne tvari u matrici hidrofilnog polimera, poli(vinil-pirolidona). Dobivene čvrste disperzije karakterizirane su diferencijalnom pretražnom kalorimetrijom i Fourier-transformiranom infracrvenom spektroskopijom. Sadržaj djelatne tvari u čvrstim disperzijama pripravljenim metodom isparavanja otapala određen je UV/Vis spektrofotometrijom i uspoređen sa sadržajem djelatne tvari u disperzijama pripravljenim metodom sušenja raspršivanjem. Bolja ujednačenost sadržaja djelatne tvari uočena je u čvrstim disperzijama pripravljenim metodom sušenja raspršivanjem.
Abstract (english)
Lurasidone hydrochloride is an active pharmaceutical ingredient with extremely low aqueous solubility that makes this drug difficult to use for the treatment of psychotic disorders. For the purpose of drug solubility enhancement, solid dispersions of a drug in a matrix of hydrophilic polymer, poly(vinylpyrrolidone), were prepared by solvent evaporation method. Derived solid dispersions were characterized by differential scanning calorimetry and Fourier- transform infrared spectroscopy. The drug content in solid dispersions prepared by solvent evaporation method was detected by UV/Vis spectrophotometry and compared with the drug content in dispersions prepared by spray drying method. Better drug content uniformity was discovered in solid dispersions prepared by spray drying method.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:292549
Study programmeTitle: Materials Science and Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2023-05-29 08:24:23