prikaz prve stranice dokumenta Validacija kromatografske metode za određivanje cefdinira
Access restricted to students and staff of home institution
undergraduate thesis
Validacija kromatografske metode za određivanje cefdinira
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. urn:nbn:hr:149:127240
Štrkalj, Ines
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Štrkalj, I. (2019). Validacija kromatografske metode za određivanje cefdinira (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:127240

Štrkalj, Ines. "Validacija kromatografske metode za određivanje cefdinira." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:127240

Štrkalj, Ines. "Validacija kromatografske metode za određivanje cefdinira." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:149:127240

Štrkalj, I. (2019). 'Validacija kromatografske metode za određivanje cefdinira', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 17 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:127240

Štrkalj I. Validacija kromatografske metode za određivanje cefdinira [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2019 [cited 2024 November 17] Available at: https://urn.nsk.hr/urn:nbn:hr:149:127240

I. Štrkalj, "Validacija kromatografske metode za određivanje cefdinira", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:149:127240

Metadata
TitleValidacija kromatografske metode za određivanje cefdinira
Title (english)Validation of chromatographic method for the determination of cefdinir
AuthorInes Štrkalj
MentorSandra Babić (mentor)
Committee memberSandra Babić (predsjednik povjerenstva)
Committee memberDragana Vuk (član povjerenstva)
Committee memberMartina Biošić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2019-09-11, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Svakodnevna primjena farmaceutika dovela je do njihove konstantne prisutnosti u okolišu, pogotovo u površinskim vodama te tlu i sedimentu. Čak iako su prisutni u niskim koncentracijama mogu značajno poremetiti ekološku ravnotežu, zbog toga je vrlo bitno razviti analitičke metode koje će omogućavati njihovo praćenje u okolišu. Svaka analitička metoda mora osigurati pouzdane rezultate, a upravo to se postiže validacijom metode. U ovom radu validirana je metode tekućinske kromatografije povezana s detektorom s nizom dioda (HPLC-DAD) za određivanje cefdinira u uzorcima površinskih voda i sintetske otpadne vode. Tijekom validacije određene su izvedbene karakteristike metode (selektivnost/specifičnost, istinitost, preciznost, linearnost, područje primjene, granica kvantifikacije, granice detekcije i stabilnost otopine cefdinira) na temelju čega je zaključeno da je metoda primjenjiva za određivanje cefdinira u vodi. Validacija je provedena s otopinama cefdinira pripremljenim u MilliQ, morskoj, izvorskoj te sintetskoj otpadnoj vodi. Ovo istraživanje i dobiveni rezultati poslužit će kao primjer kako validirati analitičku metodu i dat će uvid u analitičku metodu za određivanje cefdinira koja se može koristiti u budućim istraživanjima.
Abstract (english)
Many pharmaceuticals and personal care products have been detected as aquatic pollutants all over the world. Even if they are present in low concentration, they can have a negative effects on the environment. Therefore, it is very important to develop analytical methods for monitoring pharmaceuticals concentration in the environment. Every analytical method should provide reliable results which is achieved with validation. In this work, high performance liquid chromatography coupled to diode array detector (HPLC-DAD) for the determination of pharmaceutical cefdinir in the environmental waters is validated. During the validation performance, characteristics (selectivity/specificity, accuracy, precision, linearity, working range, limit of quantitation, limit of detection and sample stability) of the method was evaluated and it was concluded that HPLC-DAD method is suitable for its purpose. Cefdinir solutions were prepared in MilliQ, sea water, well water and synthetic wastewater. This research and the results obtained will serve as an example of how to validate the analytical method and provide an insight into a valid analytical method for determining the cefdinir that can be used in future research.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:127240
ProjectNumber: IP-2014-09-2353
Title: Sudbina farmaceutika u okolišu i tijekom naprednih postupaka obrade voda
Title: Fate of pharmaceuticals in the environment and during advanced wastewater treatment
Acronym: PharmaFate
Leader: Sandra Babić
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Advanced materials and technologies
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2023-05-29 10:07:18