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undergraduate thesis
Optimiranje uvjeta priprave čvrstih disperzija djelatne tvari u planetarnom kugličnom mlinu
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. urn:nbn:hr:149:450945
Juranović, Petra
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Juranović, P. (2023). Optimiranje uvjeta priprave čvrstih disperzija djelatne tvari u planetarnom kugličnom mlinu (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:450945

Juranović, Petra. "Optimiranje uvjeta priprave čvrstih disperzija djelatne tvari u planetarnom kugličnom mlinu." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:450945

Juranović, Petra. "Optimiranje uvjeta priprave čvrstih disperzija djelatne tvari u planetarnom kugličnom mlinu." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:450945

Juranović, P. (2023). 'Optimiranje uvjeta priprave čvrstih disperzija djelatne tvari u planetarnom kugličnom mlinu', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:450945

Juranović P. Optimiranje uvjeta priprave čvrstih disperzija djelatne tvari u planetarnom kugličnom mlinu [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2023 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:450945

P. Juranović, "Optimiranje uvjeta priprave čvrstih disperzija djelatne tvari u planetarnom kugličnom mlinu", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:149:450945

Metadata
TitleOptimiranje uvjeta priprave čvrstih disperzija djelatne tvari u planetarnom kugličnom mlinu
Title (english)Optimizing the conditions for preparation of solid dispersions of drug in a planetary ball mill
AuthorPetra Juranović
MentorKrunoslav Žižek (mentor)
Committee memberKrunoslav Žižek (predsjednik povjerenstva)
Committee memberStanislav Kurajica (član povjerenstva)
Committee memberAna Petračić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2023-07-07, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Djelatna tvar X je izrazito male topljivosti u vodenom mediju što otežava njezinu primjenu u liječenju leukemije. S ciljem povećanja njezine topljivosti pripravljene su čvrste disperzije djelatne tvari u matrici hidrofilnog polimera poli(vinil-pirolidona) (PVP). U pripravi disperzija korišten je pristup koji prati načela zelene kemije. Mehanokemijski su pripravljene disperzije čvrste djelatne tvari X u planetarnom kugličnom mlinu. Dobivene disperzije karakterizirane su diferencijalnom pretražnom kalorimetrijom, rendgenskom difrakcijskom analizom praha i infracrvenom spektroskopijom. Detektirani su optimalni procesni uvjeti za uspješnu mehanokemijsku pripravu binarne čvrste disperzije specifična djelatna tvar- polimer. Pripravljene su kapsule s čvrstim disperzijama djelatne tvari i testirane na topljivost. Mehanokemijskim tretmanom povećava se količina oslobođene djelatne tvari. Profili oslobađanja ukazuju na poboljšanu topljivost i brže oslobađanje djelatne tvari iz kapsula koje sadrže čvrste disperzije u odnosu na one koje sadrže netretiranu djelatnu tvar.
Abstract (english)
Drug X is of extremely low solubility in an aqueous medium, which makes it difficult to use in the treatment od leukemia. In order to increase its solubility, solid dispersions of a drug in a matrix of hydrophilic polymer, poly(vinyl pyrrolidone) (PVP) were prepared. Approach that follows the principles of green chemistry was used to prepare dispersions. Dispersions of solid drug X were prepared mechanochemically in a planetary ball mill. Obtained solid dispersions were characterized by differential scanning calorimetry, X-ray powder difraction analysis and infrared spectroscopy. Optimal process conditions for successfull mechanochemical preparation of binary solid dispersions specific drug-polymer are to be detected. Capsules with solid dispersions od drug were prepared and tested on solubility. Generally, mechanochemical treatment has been found to increase the amount of drug released. Release profiles indicate improved solubility and faster drug release from capsules filled with solid dispersions in comparison to those containing untreated drug.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:450945
Study programmeTitle: Materials Science and Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2023-07-07
Terms of useLicence In copyright icon
Created on2023-07-25 13:47:00