The development of various pharmaceuticals and their active use in medicine greatly improve the quality of people's lives. However, the intensive use of pharmaceuticals also has a bad side. Unfortunately, the production or use of pharmaceuticals releases certain amounts of these chemicals into the environment, so it is important to know the behavior of pharmaceuticals in different ecosystems. Pharmaceuticals, their metabolites, and degradation (by) products have been shown to have long-term adverse effects on ecosystems. Sometimes the metabolites and degradation products themselves are more toxic than the original pharmaceutical, so it is necessary to know the degradation pathways. The aim of this work was to conduct the forced degradation study on emtricitabine and ribavirin to see what is potentially happening with the above compounds in the environment. Emtricitabine and ribavirin undergo neutral hydrolysis, alkaline hydrolysis, acid hydrolysis, photolysis, forced degradation with an oxidizing agent, and thermal degradation. The LC methods were developed and validated for each pharmaceutical. For both methods developed, linearity was confirmed with a coefficient of determination greater than 0.99, and analytical recoveries were within 70-130%. The precisions of the methods were very good with relative standard deviations of less than 2%.