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master's thesis
Principima zelene kemije do lijeka poboljšanih svojstava
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. urn:nbn:hr:149:724520
Keleković, Valentina
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Keleković, V. (2023). Principima zelene kemije do lijeka poboljšanih svojstava (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:724520

Keleković, Valentina. "Principima zelene kemije do lijeka poboljšanih svojstava." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:724520

Keleković, Valentina. "Principima zelene kemije do lijeka poboljšanih svojstava." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:724520

Keleković, V. (2023). 'Principima zelene kemije do lijeka poboljšanih svojstava', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 29 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:724520

Keleković V. Principima zelene kemije do lijeka poboljšanih svojstava [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2023 [cited 2024 December 29] Available at: https://urn.nsk.hr/urn:nbn:hr:149:724520

V. Keleković, "Principima zelene kemije do lijeka poboljšanih svojstava", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:149:724520

Metadata
TitlePrincipima zelene kemije do lijeka poboljšanih svojstava
Title (english)By the principles of green chemistry to a drug with improved properties
AuthorValentina Keleković
MentorKrunoslav Žižek (mentor)
Committee memberKrunoslav Žižek (predsjednik povjerenstva)
Committee memberIrena Škorić (član povjerenstva)
Committee memberKatarina Mužina (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2023-07-14, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Jedan od izazova s kojim se danas susreće farmaceutska industrija je slaba topljivost većine novo-sintetiziranih djelatnih tvari u intestinalnim fluidima, što rezultira i niskom bioraspoloživosti i slabim farmakoterapijskim učinkom lijeka. U ovom istraživanju, nastoji se poboljšati otapanje modelne djelatne tvari X pristupom koji poštuje načela zelene kemije. Mehanokemijski su pripravljene disperzije čvrste djelatne tvari X u matrici hidrofilnog polimera poli(vinil-pirolidona) (PVP) u planetarnom kugličnom mlinu. Dobivene disperzije karakterizirane su diferencijalnom pretražnom kalorimetrijom, rendgenskom difrakcijskom analizom praha i infracrvenom spektroskopijom. Pripravljene su tablete čiste netretirane djelatne tvari, mehanokemijski tretirane djelatne tvari, te tablete s čvrstim disperzijama i fizikalne mješavine djelatne tvari i polimera. U pripravi tableta promjera 8 mm korištene su pomoćne tvari poli(etilen-glikol), natrijeva kroskarmeloza, i manitol te postupak granuliranja taljenjem u fluidiziranom sloju. Karakterizacija tableta uključivala je ispitivanje ujednačenosti masa te testiranje njihove tvrdoće i raspadljivosti. Testovi otapanja i profili oslobađanja ukazuju da mehanokemijski tretman pogoduje većoj količini oslobođene djelatne tvari. Brže oslobađanje djelatne tvari pokazuju tablete bez polimernog nosača. Tablete koje sadrže polimer poli(vinil-pirolidon) pokazuju sporije, ali kontinuirano oslobađanje djelatne tvari. Mehanokemijski pripravljene čvrste disperzije (SD) pokazuju kontinuirano oslobođanje veće količine djelatne tvari u odnosu na one koje sadrže čistu netretiranu djelatnu tvar X. Testirana je primjenjivost modela u opisu profila oslobađanja djelatne tvari X.
Abstract (english)
One of the challenges faced by the pharmaceutical industry is the low intestinal solubility of most newly synthesised drugs, resulting in low bioavailability and poor pharmacotherapeutic efficacy of the drug. In this research, an attempt is made to improve the dissolution of drug X through an approach that follows the principles of green chemistry. Dispersions of solid drug X in a matrix of hydrophilic polymer, poly(vinyl pyrrolidone) (PVP) were prepared mechanochemically in a planetary ball mill The prepared solid dispersions were characterized by differential scanning calorimetry, X-ray powder diffraction and infrared spectroscopy. Tablets were prepared with pure untreated drug, with mechanochemically treated drug, and with solid dispersions and physical mixtures of drug and polymer. Excipients like polyethylene glycol, croscarmellose sodium, mannitol, and fluidized bed melt granulation were used to prepare tablets with a diameter of 8 mm. Characterization of the tablets included studying the mass uniformity, and testing its hardness and disintegration. Dissolution tests and release profiles indicate that mechanochemical treatment favors greater amount of drug released. Tablets without polymeric carrier show faster drug release. Tablets that contain polymer poly(vinyl pyrrolidone) show slower and continuous drug release. Mechanochemically prepared solid dispersions (SD) indicate continuous release of higher amount of drug in comparision to those containing pure untreated drug X. The applicability of mathematical models was tested to describe release profiles of drug X.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:724520
Study programmeTitle: Chemical Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2023-07-14
Terms of useLicence In copyright icon
Created on2023-07-27 13:08:09