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undergraduate thesis
Sinteza, analiza fizikalno-kemijskih svojstava i biološka aktivnost novih heteroaromatskih derivata rezveratrola
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. urn:nbn:hr:149:859998
Bulava, Karla
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Bulava, K. (2023). Sinteza, analiza fizikalno-kemijskih svojstava i biološka aktivnost novih heteroaromatskih derivata rezveratrola (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:859998

Bulava, Karla. "Sinteza, analiza fizikalno-kemijskih svojstava i biološka aktivnost novih heteroaromatskih derivata rezveratrola." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:859998

Bulava, Karla. "Sinteza, analiza fizikalno-kemijskih svojstava i biološka aktivnost novih heteroaromatskih derivata rezveratrola." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:859998

Bulava, K. (2023). 'Sinteza, analiza fizikalno-kemijskih svojstava i biološka aktivnost novih heteroaromatskih derivata rezveratrola', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:859998

Bulava K. Sinteza, analiza fizikalno-kemijskih svojstava i biološka aktivnost novih heteroaromatskih derivata rezveratrola [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2023 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:859998

K. Bulava, "Sinteza, analiza fizikalno-kemijskih svojstava i biološka aktivnost novih heteroaromatskih derivata rezveratrola", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:149:859998

Metadata
TitleSinteza, analiza fizikalno-kemijskih svojstava i biološka aktivnost novih heteroaromatskih derivata rezveratrola
Title (english)Synthesis, analysis of physico-chemical properties and biological activity of new heteroaromatic derivatives of resveratrol
AuthorKarla Bulava
MentorIrena Škorić (mentor)
Committee memberIrena Škorić (predsjednik povjerenstva)
Committee memberDragana Vuk (član povjerenstva)
Committee memberDanijela Ašperger (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2023-09-04, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Tijekom izrade završnog rada provedena je sinteza novih heteroaromatskih derivata rezveratrola kao potencijalnih antioksidansa. Spojevi 2-6 sintetizirani su Wittigovom reakcijom odgovarajućeg aldehida i fosfonijeve soli kao smjese izomera, iz kojih su kasnije tankoslojnom, kolonskom i preparativnom kolonskom kromatografijom izdvojeni čisti izomeri. Spojevi 3 i 4 uspješno su dobiveni u cis- i trans-konfiguraciji, dok je kod ostalih nastajao uglavnom samo trans-izomer. Svi su spojevi spektroskopski okarakterizirani tehnikama UV te 1H i 13C NMR. Ispitivanja biološke aktivnosti provedena su u smislu istraživanja njihove antioksidacijske aktivnosti na stabilizaciju DPPH radikala i mogućnost inhibicije acetilkolinesteraze i butirilkolinesteraze.
Abstract (english)
During the preparation of the final thesis, the synthesis of new heteroaromatic derivatives of resveratrol as potential antioxidants was conducted. Compounds 2-6 were synthesized through the Wittig reaction of the corresponding aldehyde and phosphonium salt as mixtures of isomers, from which pure isomers were later separated using thin-layer, column and preparative column chromatography. Compounds 3 and 4 were successfully obtained in cis- and trans-configurations, while the others were obtained in the reaction mainly as trans-isomers. All compounds were spectroscopically characterized using UV and 1H and 13C NMR techniques. Biological activity testing was conducted to explore their antioxidant activity in stabilizing DPPH radicals and the potential inhibition of acetylcholinesterase and butyrylcholinesterase.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:859998
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2023-09-06 11:41:24