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undergraduate thesis
Sinteza i spektroskopska karakterizacija novih derivata imidazo[4,5-b]piridina kao potencijalnih senzora za pH u otopinama
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. urn:nbn:hr:149:995197
Jaklenec, Laura
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Jaklenec, L. (2023). Sinteza i spektroskopska karakterizacija novih derivata imidazo[4,5-b]piridina kao potencijalnih senzora za pH u otopinama (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:995197

Jaklenec, Laura. "Sinteza i spektroskopska karakterizacija novih derivata imidazo[4,5-b]piridina kao potencijalnih senzora za pH u otopinama." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:995197

Jaklenec, Laura. "Sinteza i spektroskopska karakterizacija novih derivata imidazo[4,5-b]piridina kao potencijalnih senzora za pH u otopinama." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:995197

Jaklenec, L. (2023). 'Sinteza i spektroskopska karakterizacija novih derivata imidazo[4,5-b]piridina kao potencijalnih senzora za pH u otopinama', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:995197

Jaklenec L. Sinteza i spektroskopska karakterizacija novih derivata imidazo[4,5-b]piridina kao potencijalnih senzora za pH u otopinama [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2023 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:995197

L. Jaklenec, "Sinteza i spektroskopska karakterizacija novih derivata imidazo[4,5-b]piridina kao potencijalnih senzora za pH u otopinama", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:149:995197

Metadata
TitleSinteza i spektroskopska karakterizacija novih derivata imidazo[4,5-b]piridina kao potencijalnih senzora za pH u otopinama
Title (english)Synthesis and spectroscopic characterization of novel imidazo[4,5-b]pyridines as potential sensors for pH in solutions
AuthorLaura Jaklenec
MentorMarijana Hranjec (mentor)
Committee memberMarijana Hranjec (predsjednik povjerenstva)
Committee memberIda Boček Pavlinac (član povjerenstva)
Committee memberPetar Kassal (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2023-09-07, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U ovom radu sintetizirane su Schiffove baze imidazo[4,5-b]piridina. Kako bi se priredili željeni derivati imidazo[4,5-b]piridina 10-12 korištene su klasične reakcije organske sinteze. Sinteza željenih spojeva započeta je sintezom N-metil-3-nitropiridin-2-amina 3 koji je priređen reakcijom 2-klor-3-nitropiridina 1 s metilaminom u etanolu uz zagrijavanje reakcijske smjese. Redukcijom, zagrijavanjem etanolne otopine spoja 3 s SnCl2×2H2O, priređen je 2-N-metilpiridin-2,3-diamin 4. Iz spoja 4 i p-aminobenzojeve kiseline 5, priređen je glavni amino-supstituirani prekursor 6. Schiffove baze 10-12 priređene su iz prekursora 6 i odgovarajućih aldehida 7-9, u apsolutnom etanolu uz dodatak octene kiseline. Strukture priređenih spojeva potvrđene su 1H i 13C NMR spektroskopijom, a spojevi 10-12 dodatno su okarakterizirani UV/Vis spektroskopijom u otapalima različite polarnosti. Ispitana je i mogućnost primjene Schiffovih baza 10-12 kao optičkih pH senzora, praćenjem promjene intenziteta apsorbancije spojeva ovisno o različitim pH vrijednostima pufera. Provedenim ispitivanjima utvrđena je mogućnost korištenja priređenih Schiffovih baza 10-12 kao optičkih pH senzora.
Abstract (english)
The aim of this work was the sythesis of imidazo[4,5-b]pyridine Schiff bases. Classic organic reactions were used for preparation of novel imidazo[4,5-b]pyridine derivatives 10-12. Their synthesis began with synthesis of N-methyl-3-nitropyridin-2-amine 3, which was prepared from 2-chloro-3-nitropyridine 1 and methylamine in ethanol by heating the reaction mixture. Within the reduction of ethanol solution of compound 3 and SnCl2×2H2O, the 2-N-methylpyridine-2,3-diamine 4 was prepared. Furthermore, from compound 4 and p-aminobenzoic acid 5, the main amino substitued precursor 6 was prepared. Schiff bases 10-12 were prepared from precursor 6 and aldehydes 7-9 in absolute ethanol with an addition of acetic acid. Structures of prepared compounds were confirmed with 1H and 13C NMR spectroscopy. Schiff bases 10-12 were also characterized by UV/Vis spectroscopy in solvents with different polarity. The possibility of using prepared Schiff bases 10-12 as optical pH sensors was also tested by tracking change in absorbance intensity of the compounds depending on the different pH values of buffer solutions. Conducted experiments have proven possibility of using prepared Schiff bases 10-12 as optical pH sensors.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:995197
ProjectNumber: IP-2018-01-4379
Title: Istraživanje antioksidativnog djelovanja benzazolskog skeleta u dizajnu novih antitumorskih agensa
Acronym: AntioxPot
Leader: Marijana Hranjec
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
ProjectNumber: IP-2020-02-8090
Title: Dizajn, sinteza i računalna analiza novih optičkih kemijskih pH osjetilnih derivata benzazola
Title: Design, Synthesis and Computational Analysis of Novel Optical Chemical pH Sensing Benzazole Derivatives
Acronym: BenzpHSens
Leader: Robert Vianello
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Chemical Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2024-04-01
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Created on2023-09-12 11:46:43