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undergraduate thesis
Određivanje topljivosti i karakterizacija djelatne tvari
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. urn:nbn:hr:149:358476
Lerotić, Bianca
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Lerotić, B. (2023). Određivanje topljivosti i karakterizacija djelatne tvari (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:358476

Lerotić, Bianca. "Određivanje topljivosti i karakterizacija djelatne tvari." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:358476

Lerotić, Bianca. "Određivanje topljivosti i karakterizacija djelatne tvari." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:358476

Lerotić, B. (2023). 'Određivanje topljivosti i karakterizacija djelatne tvari', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 03 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:358476

Lerotić B. Određivanje topljivosti i karakterizacija djelatne tvari [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2023 [cited 2024 November 03] Available at: https://urn.nsk.hr/urn:nbn:hr:149:358476

B. Lerotić, "Određivanje topljivosti i karakterizacija djelatne tvari", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:149:358476

Metadata
TitleOdređivanje topljivosti i karakterizacija djelatne tvari
Title (english)Determination of solubility and characterization of the active pharmaceutical ingredient
AuthorBianca Lerotić
MentorJasna Prlić Kardum (mentor)
Committee memberJasna Prlić Kardum (predsjednik povjerenstva)
Committee memberAleksandra Sander (član povjerenstva)
Committee memberLidija Furač (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2023-09-08, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Farmaceutska industrija je danas jedna od najrazvijenijih industrija. Podaci o topljivosti djelatne tvari i kemijskih međuproizvoda koji se koriste u farmaceutskoj industriji osnovni su podatci koji su potrebni za proces sinteze i pročišćavanja. Osim toga, s gotovo 40% spojeva koji se koriste kao lijekovi imaju problem s topljivosti. Stoga je svaki pokušaj predviđanja topljivosti vrlo važan u istraživanjima otkrivanja lijekova. U radu je određena topljivost dviju djelatnih tvari, dronedaron hidroklorida i ceritiniba u različitim otapalima i smjesama otapala. Dobiveni eksperimentalni podaci (dronedaron hidroklorid i ceritinib) te literaturni podaci (dronedaron hidroklorid) korelirani su različitim jednadžbama kao što su modificirana Apelblatova, Yawsova i Van’t Hoffova jednadžba. Sve jednadžbe dobro opisuju dobivene podatke, a bolje slganje esperimentalnih i računski određenih podataka ovisi o komponenti čija se topljivost određuje, rasponu ispitivanog temperaturnog područja, otapalu te eksperimentalnoj metodi.
Abstract (english)
Today, the pharmaceutical industry is among the most advanced industries. Data on the solubility of the active substance and chemical intermediates used in the pharmaceutical industry are the fundamental data required for the synthesis and purification process. In addition, nearly forty percent of pharmaceutical compounds have solubility issues. Consequently, any attempt to predict solubility is crucial to drug discovery research. This study determined the solubility of two active substances, dronedarone hydrochloride and ceritinib, in various solvents and solvent mixtures. This study examined the solubility of two active compounds, ceritinib and dronedarone hydrochloride, in various solvents and solvent combinations. Dronedarone hydrochloride and ceritinib obtained from the experiments and Dronedarone hydrochloride from the literature were correlated using a variety of equations, including the modified Apelblat, Yaws, and Van't Hoff equations. The better agreement between experimental and computationally calculated data depends on the component whose solubility is determined, the range of the tested temperature range, the solvent, and the experimental method. All equations adequately describe the given data.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:358476
ProjectNumber: KK.01.1.1.07.0017
Title: Napredno vođenje procesa kristalizacije
Title: Advanced Control of Crystallization Process
Acronym: CrystAPC
Leader: Nenad Bolf
Jurisdiction: Croatia
Funder: EK
Funding stream: EFRR
Study programmeTitle: Chemical Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-09-12 13:38:01