prikaz prve stranice dokumenta Sinteza novih hibrida kumarina i izoksazola s potencijalnim antitumorskim djelovanjem
Embargo period 2026-09-01
undergraduate thesis
Sinteza novih hibrida kumarina i izoksazola s potencijalnim antitumorskim djelovanjem
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. urn:nbn:hr:149:731358
Ilijov, Robert
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Ilijov, R. (2023). Sinteza novih hibrida kumarina i izoksazola s potencijalnim antitumorskim djelovanjem (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:731358

Ilijov, Robert. "Sinteza novih hibrida kumarina i izoksazola s potencijalnim antitumorskim djelovanjem." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:731358

Ilijov, Robert. "Sinteza novih hibrida kumarina i izoksazola s potencijalnim antitumorskim djelovanjem." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:731358

Ilijov, R. (2023). 'Sinteza novih hibrida kumarina i izoksazola s potencijalnim antitumorskim djelovanjem', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 04 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:731358

Ilijov R. Sinteza novih hibrida kumarina i izoksazola s potencijalnim antitumorskim djelovanjem [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2023 [cited 2024 November 04] Available at: https://urn.nsk.hr/urn:nbn:hr:149:731358

R. Ilijov, "Sinteza novih hibrida kumarina i izoksazola s potencijalnim antitumorskim djelovanjem", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:149:731358

Metadata
TitleSinteza novih hibrida kumarina i izoksazola s potencijalnim antitumorskim djelovanjem
Title (english)Synthesis of novel coumarin-isoxazole hybrids with potential antitumor activity
AuthorRobert Ilijov
MentorSilvana Raić-Malić (mentor)
Committee memberSilvana Raić-Malić (predsjednik povjerenstva)
Committee memberDragana Vuk (član povjerenstva)
Committee memberDanijela Ašperger (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2023-09-13, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Cilj ovog rada bio je sintetizirati i spektroskopski okarakterizirati nove hibride kumarina i izoksazola s potencijalnim antitumorskim djelovanjem. Spojevi (6a−h) su sintetizirani bazno kataliziranom reakcijom 1,3-dipolarne cikloadicije O-alkiliranog derivata kumarina (2) i kloriranih oksima (5a−h). Spoj 2 pripravljen je propargiliranjem 4-hidroksikumarina (1). Klorirani oksimi (5a−h) sintetizirani su kloriranjem benzaldehidoksima (4a−h) s N-klorsukcinimidom. Strukture spojeva potvrđene su spektroskopijom 1H i 13C NMR. U tijeku je ispitivanje antitumorske aktivnosti novosintetiziranih spojeva.
Abstract (english)
The aim of this work was to synthesize and spectroscopically characterize new coumarine-isoxazole hybrids with potential anticancer activity. Compounds (6a−h) were synthesized by the base-catalyzed 1,3-dipolar cycloaddition from O-alkylated coumarine derivative (2) and chlorinated oximes (5a−h). Compound 2 was prepared by propargylation of 4-hydroxycoumarine (1). Chlorinated oximes (5a−h) were synthesized from benzaldehyde oximes (4a−h) with N-chlorosuccinimide. The structures of compounds were confirmed by 1H and 13C NMR spectroscopy. Anticancer evaluations of the newly synthesized compounds are in progress.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:731358
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2026-09-01
Terms of useLicence In copyright icon
Created on2023-09-14 11:47:55