prikaz prve stranice dokumenta Sinteza i strukturna karakterizacija novih konjugata kinolina i izoksazola
Embargo period 2026-09-01
undergraduate thesis
Sinteza i strukturna karakterizacija novih konjugata kinolina i izoksazola
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. urn:nbn:hr:149:844507
Senčar, Vida
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Senčar, V. (2023). Sinteza i strukturna karakterizacija novih konjugata kinolina i izoksazola (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:844507

Senčar, Vida. "Sinteza i strukturna karakterizacija novih konjugata kinolina i izoksazola." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:844507

Senčar, Vida. "Sinteza i strukturna karakterizacija novih konjugata kinolina i izoksazola." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:844507

Senčar, V. (2023). 'Sinteza i strukturna karakterizacija novih konjugata kinolina i izoksazola', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 18 September 2024, https://urn.nsk.hr/urn:nbn:hr:149:844507

Senčar V. Sinteza i strukturna karakterizacija novih konjugata kinolina i izoksazola [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2023 [cited 2024 September 18] Available at: https://urn.nsk.hr/urn:nbn:hr:149:844507

V. Senčar, "Sinteza i strukturna karakterizacija novih konjugata kinolina i izoksazola", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:149:844507

Metadata
TitleSinteza i strukturna karakterizacija novih konjugata kinolina i izoksazola
Title (english)Synthesis and structural characterization of new quinoline-isoxazole conjugates
AuthorVida Senčar
MentorSilvana Raić-Malić (mentor)
Committee memberSilvana Raić-Malić (predsjednik povjerenstva)
Committee memberDragana Vuk (član povjerenstva)
Committee memberDanijela Ašperger (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2023-09-13, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Cilj ovog rada bio je sintetizirati nove konjugate kinolina i izoksazola koji imaju potencijalno antitumorsko djelovanje. U tu svrhu, iz anilina te β-ketoestera pripremljen je 4-hidroksi-kinolin (1) koji je reakcijom propargiliranja preveden u O-propargilirani derivat (2). U sljedećem stupnju provedeno je kloriranje aldoksima (3−6). Reakcijom 1,3-dipolarne cikloadicije O-propargiliranog kinolina (2) i kloriranog aldoksima (7−11) dobivena su četiri konjugata kinolina i izoksazola (12−15). Strukture novosintetiziranih konjugata potvrđene su spektroskopijom 1H i 13C NMR. Biološka ispitivanja pripremljenih spojeva su u tijeku.
Abstract (english)
The aim of this work was to synthesize new quinoline and isoxazole conjugates with potential antitumor activity. For this purpose, 4-hydroxy quinoline (1) was prepared from aniline and β-ketoester, which was converted into O-propargylated quinoline (2) by a propargylation reaction. Chlorinated aldoxime (7−11) were prepared by the chlorination reaction of the corresponding aldoxime (3−6). Four conjugates of quinoline and isoxazole (12−15) were obtained by the 1,3-dipolar cycloaddition reaction of O-propargylated quinoline (2) and chlorinated aldoxime (7−11). The structures of the newly synthesized conjugates were determined by 1H and 13C NMR spectroscopy. Biological evalutions of the prepared compounds are in progress.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:844507
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2026-09-01
Terms of useLicence In copyright icon
Created on2023-09-14 11:57:35