Phenol, one of the most common organic water pollutants, is highly toxic even in low concentrations. Phenol is often used in various industrial processes such as production of adhesives, petrochemical industry, construction and automotive industry. Result is that phenol ends up in the wastewater from these industries. Before releasing into the environment, phenol must be removed from wastewater. Advanced oxidation processes have emerged as a very effective solution for removing phenol from wastewater. In these processes, with the consumption of energy, reactive radicals are formed and they react with organic compound and produce water and carbon dioxide. The purpose of this work was to perform the treatment of water contamined with phenol and to investigate the influence of process parameters on the efficiency of the treatment. An advanced oxidation technique was used with UVC radiation and hydrogen peroxide or sodium persulfate as an oxidizing agent. For this purpose, a full factorial design of the experiment was created at three levels. The influence of process parameters, pH (from 4 to 10) and oxidant concentration (from 10 to 200 mM) was observed. The results of this work revealed that the pH is significant while the concentration of oxidant is not significant for UV/H2O2, while the concentration of oxidants is significant and the pH is not significant for UV/S2O8 technique. Direct photolysis of phenol by UVC radiation was also performed and the results revealed that lower pH favor the decomposition of phenol under these conditions.