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undergraduate thesis
Sinteza novih 1,3-tiazolo-stilbena kao potencijalnih inhibitora kolinesteraza i antioksidansa
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. urn:nbn:hr:149:408396
Živko, Lucija
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Živko, L. (2023). Sinteza novih 1,3-tiazolo-stilbena kao potencijalnih inhibitora kolinesteraza i antioksidansa (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:408396

Živko, Lucija. "Sinteza novih 1,3-tiazolo-stilbena kao potencijalnih inhibitora kolinesteraza i antioksidansa." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:408396

Živko, Lucija. "Sinteza novih 1,3-tiazolo-stilbena kao potencijalnih inhibitora kolinesteraza i antioksidansa." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:408396

Živko, L. (2023). 'Sinteza novih 1,3-tiazolo-stilbena kao potencijalnih inhibitora kolinesteraza i antioksidansa', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:408396

Živko L. Sinteza novih 1,3-tiazolo-stilbena kao potencijalnih inhibitora kolinesteraza i antioksidansa [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2023 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:408396

L. Živko, "Sinteza novih 1,3-tiazolo-stilbena kao potencijalnih inhibitora kolinesteraza i antioksidansa", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:149:408396

Metadata
TitleSinteza novih 1,3-tiazolo-stilbena kao potencijalnih inhibitora kolinesteraza i antioksidansa
Title (english)Synthesis of new 1,3-thiazolo-stilbenes as potential cholinesterase inhibitors and antioxidants
AuthorLucija Živko
MentorIrena Škorić (mentor)
Committee memberIrena Škorić (predsjednik povjerenstva)
Committee memberDragana Vuk (član povjerenstva)
Committee memberLidija Furač (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2023-09-14, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U cilju daljnjeg napredovanja na području sinteze spojeva koji će imati inhibicijsko djelovanje prema enzimima kolinesterazama i antioksidacijsko djelovanje, sintetizirani su novi 1,3- tiazolo-stilbeni i tieno-stilbeni. Različito supstituirani produkti (2 – 8) dobiveni su Wittigovom reakcijom iz trifenilfosfonijeve soli i odgovarajućih aldehida. U sintezi su nastali cis- i transizomeri 1,3-tiazolo-stilbena i tieno-stilbena koji su razdvajani na čiste konfiguracijske izomere kolonskom i tankoslojnom kromatografijom. Svi sintetizirani spojevi u potpunosti su spektroskopski okarakterizirani u svrhu potvrde njihove strukture. Novim 1,3-tiazolostilbenima određen je potencijal inhibicije acetil- i butirilkolinesteraze te je jednom kandidatu napravljeno i molekulsko pristajanje, kako bi se utvrdile nekovalentne interakcije koje stabiliziraju kompleks enzim-supstrat. Novim spojevima ispitivana je i potencijalna antioksidacijska aktivnost.
Abstract (english)
With the goal of advancement in the field of synthesizing compounds that will have inhibitory effects on cholinesterase enzymes and antioxidant activities, new 1,3-thiazole-stilbenes and thieno-stilbenes have been synthesized. Various substituted products (2 – 8) were obtained through the Wittig reaction from triphenylphosphonium salts and corresponding aldehydes. During the synthesis, cis- and trans-isomers of 1,3-thiazole-stilbenes and thieno-stilbenes were formed and separated into pure configurational isomers using column and thin-layer chromatography. All synthesized compounds were fully spectroscopically characterized to confirm their structures. The new 1,3-thiazolo-stilbenes were determined for their potential to inhibit acetyl- and butyrylcholinesterase, and one of the candidate was subjected to a molecular fit in order to determine the non-covalent interactions that stabilize the enzyme-substrate complex. Potential antioxidant activity was also tested with the new compounds.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:408396
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2023-09-15 11:37:07