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undergraduate thesis
Sinteza i strukturna karakterizacija novih konjugata N-supstituiranih benzimidazola
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. urn:nbn:hr:149:594711
Ravlić, Viktoria
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

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Ravlić, V. (2023). Sinteza i strukturna karakterizacija novih konjugata N-supstituiranih benzimidazola (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:594711

Ravlić, Viktoria. "Sinteza i strukturna karakterizacija novih konjugata N-supstituiranih benzimidazola." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:594711

Ravlić, Viktoria. "Sinteza i strukturna karakterizacija novih konjugata N-supstituiranih benzimidazola." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:594711

Ravlić, V. (2023). 'Sinteza i strukturna karakterizacija novih konjugata N-supstituiranih benzimidazola', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 04 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:594711

Ravlić V. Sinteza i strukturna karakterizacija novih konjugata N-supstituiranih benzimidazola [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2023 [cited 2024 November 04] Available at: https://urn.nsk.hr/urn:nbn:hr:149:594711

V. Ravlić, "Sinteza i strukturna karakterizacija novih konjugata N-supstituiranih benzimidazola", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:149:594711

Metadata
TitleSinteza i strukturna karakterizacija novih konjugata N-supstituiranih benzimidazola
Title (english)Synthesis and structural characterization of novel conjugates of N-substituted benzimidazoles
AuthorViktoria Ravlić
MentorMarijana Hranjec (mentor)
Committee memberMarijana Hranjec (predsjednik povjerenstva)
Committee memberIda Boček Pavlinac (član povjerenstva)
Committee memberLidija Furač (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2023-09-15, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U okviru ovog rada provedena je sinteza i strukturna karakterizacija novih konjugata N-supstituiranih benzimidazola. Ciljani amidino supstituirani benzamidi priređeni su uobičajenim metodama organske sinteze i mikrovalovima potpomognutom sintezom. U prvom sintetskom koraku 4-N supstituirani 3-nitrobenzonitrili 2 i 3 priređeni su mikrovalovima potpomognutom aminacijom 4-klor-3-nitrobenzonitrila 1 uz korištenje odgovarajućeg amina. U drugom koraku spojevi 2 i 3 reducirani su u diamino supstituirane benzonitrile 4 i 5 korištenjem SnCl2 x 2H2O. 2-aminobenzimidazoli 6 i 7 priređeni su ciklokondenzacijom spojeva 4 i 5 korištenjem BrCN-a. U zadnjem koraku sinteze priređeni su 2-benzimidazolil supstituirani benzamidi 10, 11 i 12 kondenzacijom spojeva 6 i 7 s odgovarajućim karboksilnim kiselinama 8 i 9. Ciljani amidino supstituirani spojevi 13 i 14 sintetizirani su Pinnerovom reakcijom u kiselom mediju iz odgovarajućeg cijano supstituiranog spoja 10. Strukture priređenih spojeva potvrđene su 1H i 13C NMR spektroskopijom, a tijek Pinnerove reakcije praćen je IR spektroskopijom.
Abstract (english)
This work presents the synthesis and structural characterization of novel conjugates of N-substituted benzimidazoles. Targeted amidino substituted benzamides were prepared by usual methods of organic chemistry and by microwave-assisted reactions. In first step of synthesis, 4-N substituted 3-nitrobenzonitriles 2 and 3 were prepared by microwave-assisted amination of 4-chloro-3-nitrobenzonitrile 1 using the corresponding amines. In second step, compounds 2 and 3 were reduced to diamino-substituted benzonitriles 4 and 5 using SnCl2 x 2H2O. 2-aminobenzimidazoles 6 and 7 were prepared by cyclocondensation of compounds 4 and 5 with BrCN. In the last step of synthesis, 2-benzimidazolyl-substituted benzamides 10, 11, and 12 were prepared by condensation of compounds 6 and 7 with the corresponding carboxylic acids 8 and 9. Targeted amidino substituted compounds 13 and 14 were synthesized by Pinner reaction in acidic medium from corresponding cyano substituted 10. Structures of prepared compounds were confirmed with 1H i 13C NMR spectroscopy, while Pinner recation was monitored by IR spectroscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:594711
ProjectNumber: IP-2018-01-4379
Title: Istraživanje antioksidativnog djelovanja benzazolskog skeleta u dizajnu novih antitumorskih agensa
Acronym: AntioxPot
Leader: Marijana Hranjec
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2024-06-01
Terms of useLicence In copyright icon
Created on2023-09-26 14:24:40