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master's thesis
Kinetička karakterizacija aldolaze imobilizirane na magnetske nanočestice
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. urn:nbn:hr:149:197164
Petrić, Ivana
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Petrić, I. (2023). Kinetička karakterizacija aldolaze imobilizirane na magnetske nanočestice (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:197164

Petrić, Ivana. "Kinetička karakterizacija aldolaze imobilizirane na magnetske nanočestice." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:197164

Petrić, Ivana. "Kinetička karakterizacija aldolaze imobilizirane na magnetske nanočestice." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:197164

Petrić, I. (2023). 'Kinetička karakterizacija aldolaze imobilizirane na magnetske nanočestice', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 30 November 2024, https://urn.nsk.hr/urn:nbn:hr:149:197164

Petrić I. Kinetička karakterizacija aldolaze imobilizirane na magnetske nanočestice [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2023 [cited 2024 November 30] Available at: https://urn.nsk.hr/urn:nbn:hr:149:197164

I. Petrić, "Kinetička karakterizacija aldolaze imobilizirane na magnetske nanočestice", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:149:197164

Metadata
TitleKinetička karakterizacija aldolaze imobilizirane na magnetske nanočestice
Title (english)Kinetic characterisation of aldolase immobilized on magnetic nanoparticles
AuthorIvana Petrić
MentorAna Vrsalović Presečki (mentor)
Committee memberAna Vrsalović Presečki (predsjednik povjerenstva)
Committee memberMartina Sudar (član povjerenstva)
Committee memberDajana Kučić Grgić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2023-09-22, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Cilj ovog rada bio je odrediti kinetiku kovalentno imobiliziranog enzima DERA u reakciji dvostruke aldolne adicije acetaldehida i kloroacetaldehida. Produkt navedene reakcije je laktol – ključni prekursor u sintezi bočnog lanca statina, lijeka za snižavanje koncentracije kolesterola u krvi. Kao nosioc za imobilizaciju, korištene su magnetske nanočestice, sintetizirane hidrotermalnom metodom, funkcionalizirane 3-aminopropiltrietoksisilanom te aktivirane 10 %-tnim anhidridom jantarne kiseline. Kinetika je za oba koraka reakcije opisana Michaelis-Menteničinom jednadžbom, a kinetički su parametri procijenjeni metodom nelinearne regresije programa MicroMath Scientist. Uz to, razvijen je matematički model procesa i validiran u kotlastom reaktoru.
Abstract (english)
The aim of this work was to determine the kinetics of the covalently immobilized DERA enzyme in the double aldol addition reaction of acetaldehyde and chloroacetaldehyde. The product of the mentioned reaction is lactol – a key precursor in the synthesis of the side chain of statin, a drug used for lowering blood cholesterol level. Magnetic nanoparticles were used as a carrier and were synthesized by the hydrothermal method, functionalized with 3-aminopropyltriethoxysilane and activated with 10 % succinic anhydride. The kinetics for both reaction steps was described by the Michaelis-Menten equation, and the kinetic parameters were estimated using the nonlinear regression method of the MicroMath Scientist software. A mathematical model of the process was also developed and validated in a batch reactor.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:197164
Study programmeTitle: Environmental Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: sveučilišni/a magistar/magistra inženjer/inženjerka ekoinženjerstva (sveučilišni/a magistar/magistra inženjer/inženjerka ekoinženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2024-10-01
Terms of useLicence In copyright icon
Created on2023-11-20 14:35:53