prikaz prve stranice dokumenta Metalni kompleksi bis-1,2,3-triazolnih liganada s različitim središnjim heteroatomom
Embargo period 2026-09-01
master's thesis
Metalni kompleksi bis-1,2,3-triazolnih liganada s različitim središnjim heteroatomom
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. urn:nbn:hr:149:747994
Šajnović, Josipa
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Šajnović, J. (2023). Metalni kompleksi bis-1,2,3-triazolnih liganada s različitim središnjim heteroatomom (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:747994

Šajnović, Josipa. "Metalni kompleksi bis-1,2,3-triazolnih liganada s različitim središnjim heteroatomom." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:747994

Šajnović, Josipa. "Metalni kompleksi bis-1,2,3-triazolnih liganada s različitim središnjim heteroatomom." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:747994

Šajnović, J. (2023). 'Metalni kompleksi bis-1,2,3-triazolnih liganada s različitim središnjim heteroatomom', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 03 January 2025, https://urn.nsk.hr/urn:nbn:hr:149:747994

Šajnović J. Metalni kompleksi bis-1,2,3-triazolnih liganada s različitim središnjim heteroatomom [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2023 [cited 2025 January 03] Available at: https://urn.nsk.hr/urn:nbn:hr:149:747994

J. Šajnović, "Metalni kompleksi bis-1,2,3-triazolnih liganada s različitim središnjim heteroatomom", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:149:747994

Metadata
TitleMetalni kompleksi bis-1,2,3-triazolnih liganada s različitim središnjim heteroatomom
Title (english)Metal complexes of bis-1,2,3-triazole ligands with various central heteroatoms
AuthorJosipa Šajnović
MentorSilvana Raić-Malić (mentor)
Committee memberSilvana Raić-Malić (predsjednik povjerenstva)
Committee memberTatjana Gazivoda Kraljević (član povjerenstva)
Committee memberSrećko Kirin (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2023-09-28, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
1,2,3-triazol predstavlja bitan farmakofor u dizajnu lijekova, a njegovi derivati stvaraju koordinativno-kovalentne veze s metalnim ionima što ih čini dobrim kandidatima u području anorganske medicinske kemije. U ovom radu opisana je sinteza simetričnih triazolnih tridentatnih liganada te njihovih metalnih kompleksa. Sinteza liganada provedena je regioselektivnom reakcijom 1,3-dipolarne cikloadicije dipropargilamina, dipropargil-etera i dipropargil-sulfida s aromatskim azidima kataliziranom bakrom(I). Strukture svih pripravljenih liganada potvrđene su spektroskopijom 1H i 13C NMR te FTIR. Novosintetizirani ligandi 5a–5d, 6a–6d i 7a–7d korišteni su za sintezu metalnih kompleksa s bakrom(II), cinkom(II), kobaltom(II) i niklom(II). Struktura i stabilnost sintetiziranih kompleksa potvrđena je pomoću spektroskopije UV-Vis i 1H NMR. Za ligand 6b i komplekse [Co(5d)2](NO3)2, [Cu(6d)2](CF3SO3)2, [Ni(7a)2](BF4)2 i [Ni(7b)2](BF4)2 određene su kristalne strukture pomoću rendgenske difrakcije na jediničnom kristalu. Dobivene kristalne strukture metalnih kompleksa ML2 stehiometrije pokazuju trans-fac stereokemiju.
Abstract (english)
1,2,3-triazole is a significant pharmacophore in drug design, while its derivatives form coordinative-covalent bonds with metal ions, which makes them good candidates in the field of inorganic medicinal chemistry. In this work, the syntheses of symmetric triazole tridentate ligands and their metal complexes were described. The syntheses of ligands were performed by the regioselective reaction of 1,3-dipolar copper(I)-catalyzed cycloaddition of dipropargyl amine, dipropargyl ether and dipropargyl sulfide with aromatic azides. The structures of the prepared ligands were confirmed by infrared spectroscopy and 1H and 13C NMR spectroscopy. The newly synthesized ligands 5a–5d, 6a–6d and 7a–7d were used for the preparation of metal complexes with copper(II), zinc(II), cobalt(II) and nickel(II). The structure and stability of the synthesized complexes were confirmed by UV-Vis and 1H NMR spectroscopy. For ligand 6b and complexes [Co(5d)2](NO3)2, [Cu(6d)2](CF3SO3)2, [Ni(7a)2](BF4)2 and [Ni(7b)2](BF4)2 crystal structures were determined by single-crystal X-ray diffraction. The crystal structures of metal complexes of ML2 stoichiometry show trans-fac stereochemistry.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:747994
ProjectNumber: KK.01.1.1.04.0013
Title: Inovativna rješenja u katalitičkim proizvodnim procesima za potrebe farmaceutske industrije
Title: Innovative solutions in catalytic processes in the pharmaceutical industry
Acronym: CAT PHARMA
Leader: Srećko Kirin
Jurisdiction: eu
Funder: EC
Funding stream: EFRR
Study programmeTitle: Applied Chemistry - Graduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: graduate
Academic / professional title: sveučilišni/a magistar/magistra primijenjene kemije (sveučilišni/a magistar/magistra primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2026-09-01
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Created on2023-11-24 10:30:56