Most of the active substances are produced in solid form, and crystallization is extremely important for the pharmaceutical industry. One of the methods that improves the granulometric properties of crystals is spherical crystallization, in which spherical crystals are formed, which reduces the number of steps in drug formulation. The purpose of this work was to determine the solvent system for spherical crystallization using different processes and to examine the influence of different hydrodynamic conditions on the granulometric properties of the obtained crystals. The conditions for the implementation of spherical crystallization are determined for the active substance ceritinib, which is used in the treatment of non-small cell lung cancer. As part of the preliminary experiments, the Dynochem software system was used to select the bridging fluid. The chosen system contains the solvent THF, water used as an antisolvent, the bridging liquid heptane and the polymer PVP (polyvinylpyrrolidone) as an additive. In order to examine the influence of process conditions on the granulometric properties of the obtained crystals, their characterization was carried out during the process and after drying. The analysis of granulometric properties was determined by the particle size distribution obtained by the laser diffraction method, the morphology of the crystals was examined by an optical electron microscope, and their structure by the X-ray diffraction method.