Hydrogels are physically or chemically cross-linked macromolecules that form a three-dimensional network capable of retaining water without disintegration. They have good elastic properties, almost identical to the tissue of a living organism. The widespread use of starch-based hydrogels in industrial and ecological fields of application is considered to be of primary importance. Starch belongs to the group of polysaccharides, built from glucose units connected in two polymer chains - amylose and amylopectin. The production and use of starch in the world is constantly increasing due to the positive effects achieved by its addition in the production of various products. Polylactic acid, PLA is a thermoplastic, biodegradable polymer produced synthetically, by polymerization of lactic acid monomers or cyclic lactide dimers. It is broken down by hydrolysis of basic polymer esters. It has numerous biomedical applications, such as sutures, stents, dialysis media, and drug delivery devices. In this work, the process of mixing starch into the PLA matrix was carried out with the aim of preparing biodegradable hydrogels that could potentially be used as matrix systems for the delivery of drugs with prolonged release in the pharmaceutical industry. The aim was to test whether starch, which is hydrophilic and mixed in small proportions in the PLA matrix, can stimulate its stronger swelling and consequently accelerate its chemical decomposition over time. The experimental part of the work included the preparation of mixtures of polylactide with a small proportion of starch (5-15 wt. %) and hydrogels by the process of phase inversion caused by the change of solvent N-methyl pyrrolidone (NMP) (solvent induced phase inversion). Hydrogels formed in water were characterized and the degree of swelling was monitored over a period of 30 days. The GPC (Gel permeation chromatography) method was used to determine whether there was a change in the molecular weight of the polylactide matrix as a result of hydrolytic decomposition. From the results obtained on the basis of the measurements, it is evident that the highest degree of swelling was achieved by the sample PLA+TPS/NMP (90:10). From the GPC results, it was established that there was no chemical degradation of the polylactide matrix, regardless of the amount and type of starch that was mixed.