prikaz prve stranice dokumenta Zelena sinteza 2-supstituiranih derivata benzoksazola s potencijalnim antitumorskim djelovanjem
Embargo period 2025-10-01
undergraduate thesis
Zelena sinteza 2-supstituiranih derivata benzoksazola s potencijalnim antitumorskim djelovanjem
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. urn:nbn:hr:149:604798
Kolarek, Leda
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Kolarek, L. (2023). Zelena sinteza 2-supstituiranih derivata benzoksazola s potencijalnim antitumorskim djelovanjem (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:604798

Kolarek, Leda. "Zelena sinteza 2-supstituiranih derivata benzoksazola s potencijalnim antitumorskim djelovanjem." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:604798

Kolarek, Leda. "Zelena sinteza 2-supstituiranih derivata benzoksazola s potencijalnim antitumorskim djelovanjem." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2023. https://urn.nsk.hr/urn:nbn:hr:149:604798

Kolarek, L. (2023). 'Zelena sinteza 2-supstituiranih derivata benzoksazola s potencijalnim antitumorskim djelovanjem', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:604798

Kolarek L. Zelena sinteza 2-supstituiranih derivata benzoksazola s potencijalnim antitumorskim djelovanjem [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2023 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:604798

L. Kolarek, "Zelena sinteza 2-supstituiranih derivata benzoksazola s potencijalnim antitumorskim djelovanjem", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:149:604798

Metadata
TitleZelena sinteza 2-supstituiranih derivata benzoksazola s potencijalnim antitumorskim djelovanjem
Title (english)Green synthesis of 2-substituted benzoxazole derivatives with antitumoral potential
AuthorLeda Kolarek
MentorTatjana Gazivoda Kraljević (mentor)
Committee memberTatjana Gazivoda Kraljević (predsjednik povjerenstva)
Committee memberDragana Vuk (član povjerenstva)
Committee memberLidija Furač (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2023-09-22, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U ovom radu opisana je konvencionalna i zelena sinteza te strukturna karakterizacija 2-supstituiranih derivata benzoksazola s potencijalnim antitumorskim djelovanjem. O-alkilirani benzaldehidi (1-4) dobiveni su reakcijom 4-hidroksibenzaldehida i 4-hidroksi-3- metoksibenzaldehida s odgovarajućim alkilirajućim reagensom. Zatim su reakcijom O-alkiliranih benzaldehida (1-4) i o-aminofenola pripravljeni derivati Schiffovih baza (5-7). Reakcijom oksidativne ciklizacije Schiffovih baza (5-7) dobiveni su 2-supstituirani derivati benzoksazola (8-9). Sinteze svih pripravljenih spojeva su provedene konvencionalno i primjenom zelenih metoda (mikrovalovima i ultrazvukom potpomognuta sinteza, mehanokemijska sinteza i sinteza u niskotemperaturnom eutektičkom otapalu). Strukturna analiza priređenih spojeva provedena je 1H- i 13C-NMR spektroskopijom.
Abstract (english)
This work describes the conventional and green synthesis as well as structural characterization of 2-substituted benzoxazole derivatives with potential antitumor activity. O-alkylated benzaldehydes (1-4) were obtained by the reaction of 4-hydroxybenzaldehyde and 4-hydroxy-3-methoxybenzaldehyde with the appropriate alkylating reagent. Derivatives of Schiff's bases (5-7) were prepared by reaction of O-alkylated benzaldehydes (1-4) with o-aminophenols. By oxidative cyclization reaction of Schiff bases (5-7), 2-substituted benzoxazole derivatives (8-9) were obtained. The syntheses of all prepared compounds were carried out conventional and by using green methods (microwave- and ultrasound-assisted synthesis, mechanochemical synthesis and synthesis in deep eutectic solvent). The structural analysis of prepared compounds were performed by 1H- and 13C-NMR spectroscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:604798
ProjectNumber: IP-2018-01-4682
Title: Novi spojevi temeljeni na bioizosterima purina za ispitivanje njihovih antitumorskih i antipatogenih djelovanja
Acronym: PurBioCaPa
Leader: Silvana Raić-Malić
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Materials Science and Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2025-10-01
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Created on2023-11-30 14:58:38