In today’s medicine, more attention is given to implant materials that serve as replacements for bones, teeth and other damaged biological structures in the human body. Titanium and its alloys are one of the most commonly used materials for making implants, due to their desirable properties including high strength, low density, good corrosion resistance, biocompatibility and bioinertness. One of the main problems in the process of implantation in the human body is the implant degradation as a result of the corrosion process. Corrosion, in addition to partial loss of implant function or premature failure, has a harmful effect on humans due to the unwanted release of metal ions that can accumulate in the surrounding tissues and organs what can lead to dangerous consequences for human health. In order to prevent corrosion, before implantation in human body, various corrosion protection modification methods can be applied, including the self-assembling monolayer coatings that provide corrosion protection to the underlying implant, and in some cases improve the properties of implant itself. Self-assembled monolayers (SAMs) are formed by the adsorption of organic molecules from a homogeneous solution and subsequent spontaneous arrangement on a solid surface into densely packed ordered structures. In this work, the emphasis is on self-organizing monolayers of phosphonic acids, which, compared to other SAMs, show better temperature stability and better hydrophobic properties and surface coverage, hence, serving as very attractive candidates in the field of materials science and surface engineering. Their role on the surface of the titanium implant is not only as a protective barrier against corrosion, but also to increase the bioactivity and improve the osseointegration of the titanium implant material, which is why they are a key factor in the long-term stability of the implant itself.