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master's thesis
Priprava i primjena koprocesiranih pomoćnih tvari
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2024. urn:nbn:hr:149:751663
Svorcina, Lucija
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Svorcina, L. (2024). Priprava i primjena koprocesiranih pomoćnih tvari (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:751663

Svorcina, Lucija. "Priprava i primjena koprocesiranih pomoćnih tvari." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2024. https://urn.nsk.hr/urn:nbn:hr:149:751663

Svorcina, Lucija. "Priprava i primjena koprocesiranih pomoćnih tvari." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2024. https://urn.nsk.hr/urn:nbn:hr:149:751663

Svorcina, L. (2024). 'Priprava i primjena koprocesiranih pomoćnih tvari', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 29 March 2025, https://urn.nsk.hr/urn:nbn:hr:149:751663

Svorcina L. Priprava i primjena koprocesiranih pomoćnih tvari [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2024 [cited 2025 March 29] Available at: https://urn.nsk.hr/urn:nbn:hr:149:751663

L. Svorcina, "Priprava i primjena koprocesiranih pomoćnih tvari", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:149:751663

Metadata
TitlePriprava i primjena koprocesiranih pomoćnih tvari
Title (english)Preparation and application of co-processed excipients
AuthorLucija Svorcina
MentorKrunoslav Žižek (mentor)
Committee memberKrunoslav Žižek (predsjednik povjerenstva)
Committee memberMarin Kovačić (član povjerenstva)
Committee memberKatarina Mužina (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2024-07-05, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Ovaj rad bavi se problemom poboljšanja topljivosti i bioraspoloživosti dasatiniba, koji se koristi za liječenje leukemije. Dasatinib ima ograničenu topljivost u vodenom mediju, što rezultira slabom i sporom apsorpcijom u gastrointestinalnom traktu te niskom bioraspoloživošću. Modifikacija topljivosti i oslobađanja dasatiniba može imati pozitivan utjecaj na oralnu apsorpciju i bioraspoloživost lijeka. Glavni cilj istraživanja je formulirati ovaj specifičan lijek primjenom koprocesirane pomoćne... More tvari. Koprocesirana pomoćna tvar pripravljena je mehanokemijskim tretmanom i granuliranjem taljenjem. Pripremljena čvrsta disperzija pomoćnih tvari karakterizirana je metodama analize koje mogu ukazati na uspješnu pripravu disperzija. Pripravljena disperzija, odnosno koprocesirana pomoćna tvar, korištena je u pripravi konačnog dozirnog oblika djelatne tvari, tableta. Mehanokemijskim tretmanom nije ostvarena željena amorfizacija pomoćnih tvari. Granuliranjem taljenjem pripravljene su čvrste disperzije mikrokristalne celuloze, D-manitola i poli(etilen-glikola). Provedena je morfološka i granulometrijska analiza pripravljenih uzoraka. Pripravljene tablete testirane su na ujednačenost masa i sadržaja, čvrstoću, raspadljivost te topljivost. Koprocesiranjem pomoćnih tvari modificiran je profil oslobađanja dasatiniba. Less
Abstract (english)
This thesis addresses the issue of improving the solubility and bioavailability of dasatinib, which is used to treat leukemia. Dasatinib has limited solubility in aqueous media, resulting in slow and poor absorption in the gastrointestinal tract and low bioavailability. Changing the solubility and release of dasatinib could have a positive effect on the oral absorption and bioavailability of the drug. The main objective of the research is to formulate this specific drug using a co-processed... More excipient. The co-processed excipient is prepared by mechanochemical treatment and melt granulation. The prepared solid dispersion of excipients was characterized using analytical methods that can give an indication of the successful preparation of dispersions. The prepared dispersion, i.e. the co-processed excipient, was used to prepare the final dosage form of the drug, the tablets. The desired amorphization of the excipients was not achieved by the mechanochemical treatment. Solid dispersions of microcrystalline cellulose, D-mannitol and poly(ethylene glycol) were prepared by melt granulation. Morphological and granulometric analysis of the prepared samples was carried out. The prepared tablets were tested for uniformity of mass and content, hardness, disintegration and solubility. The release profile of dasatinib was modified by co-processing of excipients. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:751663
Study programmeTitle: Environmental Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: sveučilišni/a magistar/magistra inženjer/inženjerka ekoinženjerstva (sveučilišni/a magistar/magistra inženjer/inženjerka ekoinženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-07-08 09:23:47
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