prikaz prve stranice dokumenta Degradation of Ribavirin and Emtricitabine by Fenton oxidation
Embargo period 2027-12-15
master's thesis
Degradation of Ribavirin and Emtricitabine by Fenton oxidation
Zagreb, Split: University of Zagreb, Faculty of Chemical Engineering and Technology, 2024. urn:nbn:hr:149:578081
Zanki, Tyler Nicholas
University of Zagreb
Faculty of Chemical Engineering and Technology
University of Split
Faculty of Chemistry and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Zanki, T. N. (2024). Degradation of Ribavirin and Emtricitabine by Fenton oxidation (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; Split: University of Split, Faculty of Chemistry and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:578081

Zanki, Tyler Nicholas. "Degradation of Ribavirin and Emtricitabine by Fenton oxidation." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology; University of Split, Faculty of Chemistry and Technology, 2024. https://urn.nsk.hr/urn:nbn:hr:149:578081

Zanki, Tyler Nicholas. "Degradation of Ribavirin and Emtricitabine by Fenton oxidation." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology; University of Split, Faculty of Chemistry and Technology, 2024. https://urn.nsk.hr/urn:nbn:hr:149:578081

Zanki, T. N. (2024). 'Degradation of Ribavirin and Emtricitabine by Fenton oxidation', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology; University of Split, Faculty of Chemistry and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:578081

Zanki TN. Degradation of Ribavirin and Emtricitabine by Fenton oxidation [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; Split: University of Split, Faculty of Chemistry and Technology; 2024 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:578081

T. N. Zanki, "Degradation of Ribavirin and Emtricitabine by Fenton oxidation", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb; University of Split, Faculty of Chemistry and Technology, Split, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:149:578081

Metadata
TitleDegradation of Ribavirin and Emtricitabine by Fenton oxidation
Title (croatian)Razgradnja antivirusnih lijekova Ribavirina i Emtricitabina Fentonovom oksidacijom
AuthorTyler Nicholas Zanki
MentorMatija Cvetnić (mentor)
Committee memberMatija Cvetnić (predsjednik povjerenstva)
Committee memberŠime Ukić (član povjerenstva)
Committee memberLidija Furač (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
GranterUniversity of Split
Faculty of Chemistry and Technology
Split
Defense date and country2024-09-25, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Along with all the benefits modern medicine has brought, they have also brought issues pertaining to their disposal. Removing medical pollutants from wastewater protects humans as well as the environment. Fenton oxidation is a quick and relatively inexpensive option to oxidize pollutants in wastewater. This thesis investigates the best conditions for Fenton oxidation to decompose two common antiviral medications: ribavirin and emtricitabine. The tested conditions were reactant concentrations and pH of the reaction. Fenton oxidation requires an iron (II) ion to hydroxyl radicals from hydrogen peroxide that then oxidize the antivirals. Iron (II) concentrations were tested against concentration of hydrogen peroxide in three concentration levels. Each experiment was conducted at three pH levels: 3, 4, and 5. High-performance liquid chromatography was employed to analyze the results. Response surface modelling was employed to determine the relationship between reactant and pollutant concentrations and the significance of those results were determined by ANOVA. The ribavirin decomposition was plagued by side reactions that reduced the available radical to decompose the medication, resulting in low decomposition but significant results. Emtricitabine decomposition fared better, resulting in complete and near-complete decomposition in one minute with significant results.
Abstract (croatian)
Uz sve prednosti koje je donijela suvremena medicina, došli su i problemi kod njihova zbrinjavanja i uklanjanja. Uklanjanje medicinskih onečišćujuća tvar iz otpadnih voda štiti ljude kao i okoliš. Fenton oksidacija je brza i relativno jeftina opcija za oksidaciju zagađivača u otpadnoj vodi. Ovaj rad istražuje najbolje uvjete za Fentonovu oksidaciju za razgradnju dva uobičajena antivirusna lijeka: ribavirin i emtricitabin. Uvjeti u ispitivanju bili su koncentracije reaktanata i pH reakcije. Fentonova oksidacija zahtijeva ion željeza (II) za razgradnju vodikovog peroksida u hidroksilne radijale koji zatim oksidiraju antivirusne lijekove. Ispitane su tri koncentracije iona željeza (II) u odnosu na tri koncentracije vodikovog peroksida. Svaki eksperiment je proveden na tri razine pH: 3, 4 i 5. Za analizu rezultata korištena je tekućinska kromatografija visoke učinkovitosti. Modeliranje površine odgovora korišteno je za određivanje odnosa između koncentracija reaktanata, a značajnost tih rezultata određena je ANOVA. Razgradnja ribavirina bila je praćena nuspojavama koje su smanjile raspoloživi radikal za razgradnju lijeka, što je rezultiralo slabom razgradnjom, ali značajnim rezultatima. Razgradnja emtricitabina bila je bolja, što je rezultiralo potpunom i gotovo potpunom razgradnjom u jednoj minuti sa značajnim rezultatima.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:149:578081
ProjectNumber: IP-2022-10-2822
Title: Okolišni aspekti SARS-CoV-2 antivirotika
Title: Environmental Aspects of SARS-CoV-2 Antiviral Substances
Acronym: EnA-SARS
Leader: Šime Ukić
Jurisdiction: Croatia
Funder: Hrvatska zaklada za znanost
Funding stream: Research Projects
Study programmeTitle: Chemical and environmental technology - graduate - university
Study programme type: university
Study level: graduate
Academic / professional title: sveučilišni/a magistar/magistra inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2027-12-15
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Created on2024-11-06 13:27:10