prikaz prve stranice dokumenta Stability study of selected pharmaceutical formulations
  Download
PDF 1.3 MB
master's thesis
Stability study of selected pharmaceutical formulations
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. urn:nbn:hr:149:473987
Ferčec, Borna
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Ferčec, B. (2016). Stability study of selected pharmaceutical formulations (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:473987

Ferčec, Borna. "Stability study of selected pharmaceutical formulations." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:149:473987

Ferčec, Borna. "Stability study of selected pharmaceutical formulations." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:149:473987

Ferčec, B. (2016). 'Stability study of selected pharmaceutical formulations', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:473987

Ferčec B. Stability study of selected pharmaceutical formulations [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2016 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:473987

B. Ferčec, "Stability study of selected pharmaceutical formulations", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:149:473987

Metadata
TitleStability study of selected pharmaceutical formulations
Title (croatian)Studija stabilnosti izabranih farmaceutskih formulacija
AuthorBorna Ferčec
MentorDragana Mutavdžić Pavlović (mentor)
Committee memberDragana Mutavdžić Pavlović (predsjednik povjerenstva)
Committee memberDanijela Ašperger (član povjerenstva)
Committee memberMarijana Hranjec (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2016-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Analytic Chemistry
Abstract
An optimized reversed phase HPLC method, for the stability study of formulations containing prostaglandin E1 and papaverine HCl as main components, was developed. Stability study will be performed at seven time points: t0 (starting point), and then after one, two, three, four, five, and finally, six months. Chromatographic separations were achieved on an Alltima C18 5μ column (250 mm x 4.6 mm, 5 μm) and maintained at room temperature using gradient elution. Mobile phase A was a mixture of a 0.02 M phosphate buffer solution (pH 3.0) and acetonitrile (62: 38 v/v). Mobile phase B was a mixture of a 0.02 M phosphate buffer solution (pH 3.0) and acetonitrile (30: 70 v/v). Mobile phases were pumped at a flow rate of 1.2 mL/min. UV detection was performed at 205 nm. The method was validated for specificity, linearity, accuracy, limit of detection, limit of quantification, and precision of the two main peaks. Stability study was performed for t0 (starting point).
Abstract (croatian)
Razvijena je i optimizirana HPLC metoda obrnute faze, za studiju stabilnosti farmaceutskih formulacija koje sadrže prostaglandin E1 i papaverin HCl kao glavne komponente. Studija stabilnosti bit će izvedena kroz sedam vremenskih točaka: t0 (početna vremenska točka), te nakon jedan, dva, tri, četiri, pet, i konačno, šest mjeseci. Kromatografska separacija postignuta je na Alltima C18 5μ koloni (250 mm x 4,6 mm, 5 μm) pri sobnoj temperaturi koristeći gradijentni protok pokretne faze. Pokretna faza A je mješavina 0,02 M fosfatnog pufera (pH 3.0) i acetonitrila (62:38 v/v). Pokretna faza B je mješavina 0,02 M fosfatnog pufera (pH 3.0) i acetonitrila (30:70 v/v). Protok pokretnih faza je 1,2 mL/min. UV detekcija izvedena je pri 205 nm. Metoda je validirana na specifičnost, linearnost, točnost, granice detekcije i kvantifikacije, te preciznost za dva glavna pika. Studija stabilnosti izvedena je za t0 (početna vremenska točka).
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:149:473987
Study programmeTitle: Chemical Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Public noteRad je napisan na engleskom jeziku, ali u radu nedostaje stvarni naslov rada na engleskom jeziku koji glasi: Stability study of selected pharmaceutical formulations (preuzeto iz Hrvatske znanstvene bibliografije).
Created on2017-05-31 12:15:40