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master's thesis
Utjecaj procesnih parametara na granulometrijska svojstva sferičnih kristala
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2024. urn:nbn:hr:149:281322
Sabol, Mirta
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Sabol, M. (2024). Utjecaj procesnih parametara na granulometrijska svojstva sferičnih kristala (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:281322

Sabol, Mirta. "Utjecaj procesnih parametara na granulometrijska svojstva sferičnih kristala." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2024. https://urn.nsk.hr/urn:nbn:hr:149:281322

Sabol, Mirta. "Utjecaj procesnih parametara na granulometrijska svojstva sferičnih kristala." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2024. https://urn.nsk.hr/urn:nbn:hr:149:281322

Sabol, M. (2024). 'Utjecaj procesnih parametara na granulometrijska svojstva sferičnih kristala', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 29 March 2025, https://urn.nsk.hr/urn:nbn:hr:149:281322

Sabol M. Utjecaj procesnih parametara na granulometrijska svojstva sferičnih kristala [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2024 [cited 2025 March 29] Available at: https://urn.nsk.hr/urn:nbn:hr:149:281322

M. Sabol, "Utjecaj procesnih parametara na granulometrijska svojstva sferičnih kristala", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:149:281322

Metadata
TitleUtjecaj procesnih parametara na granulometrijska svojstva sferičnih kristala
Title (english)The influence of process parameters on the granulometric properties of spherical crystals
AuthorMirta Sabol
MentorJasna Prlić Kardum (mentor)
Committee memberJasna Prlić Kardum (predsjednik povjerenstva)
Committee memberErnest Meštrović (član povjerenstva)
Committee memberŽeljka Ujević Andrijić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2024-09-30, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Formulacija lijekova postaje sve izazovniji proces unutar farmaceutske industrije zbog otkrivanja djelatnih tvari nepoželjnih fizikalno-kemijskih i biofarmaceutskih svojstava. Procesom sferične kristalizacije moguće je dobiti kristale djelatne tvari sferičnog oblika koji pokazuju bolja fizikalno-kemijska i biofarmaceutska svojstva te je s takvim kristalima lakše rukovati u usporedbi s kristalima koji nisu sferičnog oblika. Ovim radom ispitan je utjecaj volumnog udjela otapala, antiotapala i... More kapljevine za premoštenje u sustavu za provedbu sferične kristalizacije na granulometrijska svojstva kristala ceritiniba, lijeka koji se koristi za liječenje uznapredovalog raka pluća nemalih stanica i koji pripada IV razredu BCS-a. Kristali su karakterizirani stereomikroskopom i pretražnim elektronskim mikroskopom te je određena raspodjela veličina čestica i zaobljenost kristala. Metoda dizajna eksperimenta za proces sferične kristalizacije provedena je u softverskom programu Design Expert, gdje je dobiven model koji najbolje opisuje utjecaj volumnog udjela svakog otapala u sustavu za provedbu sferične kristalizacije ceritiniba na zaobljenost kristala. Utvrđeno je da u sustavu otapala za sferičnu kristalizaciju ceritiniba pri niskom udjelu otapala prema kapljevini za premoštenje neće nastati kristali sferičnog oblika, kao ni kod jako niskog udjela otapala u odnosu na antiotapalo. Optimizacijom procesa u Design Expertu dobiveni su sferični kristali najveće zaobljenosti od svih provedenih eksperimenta koja iznosi 0,91 što ukazuje na uspješno dizajniranje, modeliranje i optimiziranje sustava otapala za sferičnu kristalizaciju ceritiniba. Less
Abstract (english)
Drug formulation is becoming an increasingly challenging process within the pharmaceutical industry due to the discovery of active pharmaceutical ingredients with undesirable physicochemical and biopharmaceutical properties. Through the process of spherical crystallization, it is possible to obtain crystals of the active pharmaceutical ingredient with a spherical shape, which exhibit improved physicochemical and biopharmaceutical properties, and such crystals are easier to handle compared... More to non-spherical crystals. This thesis investigated the influence of the volume fraction of solvent, antisolvent, and bridging liquid in the spherical crystallization system on the granulometric properties of ceritinib crystals. Ceritinib is classified as a BCS class IV drug and is used for the treatment of advanced non-small cell lung cancer. The crystals were characterized using a stereomicroscope and a scanning electron microscope, and the particle size distribution and roundness of the crystals were determined. The design of the experiment for the spherical crystallization process was conducted using the Design Expert software, where a model that best describes the influence of the volume fraction of each solvent in the system on the roundness of ceritinib crystals was developed. It was found that in the spherical crystallization system of ceritinib, spherical crystals do not form well at a low solvent-to-bridging liquid ratio, nor at a very low solvent-to-antisolvent ratio. By optimizing the process in Design Expert, spherical crystals with the highest roundness value of 0.91 were obtained, indicating successful design, modeling, and optimization of the process. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:281322
ProjectNumber: KK.01.1.1.07.0017
Title: Napredno vođenje procesa kristalizacije
Title: Advanced Control of Crystallization Process
Acronym: CrystAPC
Leader: Nenad Bolf
Jurisdiction: eu
Funder: Europska unija
Funding stream: European Regional Development Fund
Study programmeTitle: Chemical Engineering - Graduate study
Study programme type: university
Study level: graduate
Academic / professional title: sveučilišni/a magistar/magistra inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-11-11 15:15:36
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