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undergraduate thesis
Primjena polimernih mješavina u dostavi lijeka
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2024. urn:nbn:hr:149:388930
Florijanić, Matija
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Florijanić, M. (2024). Primjena polimernih mješavina u dostavi lijeka (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:388930

Florijanić, Matija. "Primjena polimernih mješavina u dostavi lijeka." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2024. https://urn.nsk.hr/urn:nbn:hr:149:388930

Florijanić, Matija. "Primjena polimernih mješavina u dostavi lijeka." Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2024. https://urn.nsk.hr/urn:nbn:hr:149:388930

Florijanić, M. (2024). 'Primjena polimernih mješavina u dostavi lijeka', Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:388930

Florijanić M. Primjena polimernih mješavina u dostavi lijeka [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2024 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:388930

M. Florijanić, "Primjena polimernih mješavina u dostavi lijeka", Undergraduate thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:149:388930

Metadata
TitlePrimjena polimernih mješavina u dostavi lijeka
Title (english)Application of polymer blends in drug delivery
AuthorMatija Florijanić
MentorKrunoslav Žižek (mentor)
Committee memberKrunoslav Žižek (predsjednik povjerenstva)
Committee memberVanja Kosar (član povjerenstva)
Committee memberFilip Car (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2024-09-13, Croatia
Scientific / art field,
discipline and subdiscipline		TECHNICAL SCIENCES
Chemical Engineering
Abstract
Dasatinib je antikancerogeni lijek koji se koristi u liječenju kronične mijeloične i akutne limfoblastične leukemije. Zbog svoje slabe topljivosti u vodenom mediju ima ograničenu bioraspoloživost. S ciljem povećanja njegove topljivosti i modifikacije profila oslobađanja, pripravljene su ternarne čvrste disperzije s poli(vinil-pirolidonom) i hidroksipropil-metil-celulozom mljevenjem u planetarnom kugličnom mlinu. Mehanokemijska aktivacija omogućuje pripravu bez primjene otapala poštujući načela zelene kemije, a istovremeno poboljšavaju topljivost i bioraspoloživost dasatiniba. Čvrste ternarne disperzije s polimernim mješavinama i granulati pomoćnih tvari korišteni su u pripravi tableta. Dobivene tablete karakterizirane su pomoću standardiziranih farmaceutskih testova u skladu s preporukama Europske farmakopeje. Rezultati testiranja pokazali su produljeno oslobađanje djelatne tvari uz poboljšanje topljivosti u usporedbi s čistim dasatinibom, što ukazuje na potencijalno poboljšanje bioraspoloživosti i terapijske učinkovitosti lijeka. Ovaj rad jasno ukazuje na potencijal polimernih mješavina za postizanje ciljanog profila oslobađanja, a time i poboljšanje bioraspoloživosti i efikasnosti dasatiniba, što može pridonijeti boljem ishodu liječenja leukemije.
Abstract (english)
Dasatinib is an anticancer drug used in the treatment of chronic myeloid and acute lymphoblastic leukemia. Due to its poor solubility in aqueous medium, it has limited bioavailability. To increase its solubility and to modify drug release profile, ternary solid dispersions with polyvinylpyrrolidone and hydroxypropyl methylcellulose were prepared by milling in a planetary ball mill. Mechanochemical activation allows for preparation without the use of solvents, following the principles of green chemistry while simultaneously improving the solubility and bioavailability of dasatinib. Ternary solid dispersions and granulates of excipients were used in the preparation of tablets. Obtained tablets were characterized using standardized pharmaceutical tests in accordance with the European Pharmacopoeia recommendations. Testing results showed prolonged release of drug with an improvement in solubility when compared to pure dasatinib, indicating a potential enhancement in bioavailability and therapeutic efficacy of drug product. This thesis clearly indicates the potential of polymer blends to achieve aimed release profile, and thus enhacement of the bioavailability and efficiency of dasatinib, which may contribute to better treatment outcomes for leukemia.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:388930
Study programmeTitle: Environmental Engineering - Undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-11-14 14:11:52