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master's thesis
Novi biološki aktivni amino, amidino i amido supstituirani derivati fenantrena
Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. urn:nbn:hr:149:348668
Rep, Valentina
University of Zagreb
Faculty of Chemical Engineering and Technology

Institutional repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb

Cite this document

Rep, V. (2016). Novi biološki aktivni amino, amidino i amido supstituirani derivati fenantrena (Master's thesis). Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:149:348668

Rep, Valentina. "Novi biološki aktivni amino, amidino i amido supstituirani derivati fenantrena." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:149:348668

Rep, Valentina. "Novi biološki aktivni amino, amidino i amido supstituirani derivati fenantrena." Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:149:348668

Rep, V. (2016). 'Novi biološki aktivni amino, amidino i amido supstituirani derivati fenantrena', Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, accessed 20 December 2024, https://urn.nsk.hr/urn:nbn:hr:149:348668

Rep V. Novi biološki aktivni amino, amidino i amido supstituirani derivati fenantrena [Master's thesis]. Zagreb: University of Zagreb, Faculty of Chemical Engineering and Technology; 2016 [cited 2024 December 20] Available at: https://urn.nsk.hr/urn:nbn:hr:149:348668

V. Rep, "Novi biološki aktivni amino, amidino i amido supstituirani derivati fenantrena", Master's thesis, University of Zagreb, Faculty of Chemical Engineering and Technology, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:149:348668

Metadata
TitleNovi biološki aktivni amino, amidino i amido supstituirani derivati fenantrena
Title (english)Novel biologically active amino, amidino and amido substituted phenantrene derivatives
AuthorValentina Rep
MentorMarijana Hranjec (mentor)
Committee memberMarijana Hranjec (predsjednik povjerenstva)
Committee memberNataša Perin (član povjerenstva)
Committee memberDragana Mutavdžić Pavlović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Chemical Engineering and Technology
Zagreb
Defense date and country2016-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
Cilj ovog rada bio je sintetizirati nove amido 26, 27, amidino 28, 29 i amino 30, 31, 32 i 33 supstituirane derivate fenantrena i amido 46, 47, amidino 48, 49 i amino 50 supstituirane derivate nafto[2,1-b]tiofena. Za pripravu ciljnih spojeva korištene su klasične metode organske sinteze, sinteze potpomognute mikrovalnim zračenjem i fotokemijske sinteze. Sinteza amido 26, 27 i amidino 28, 29 derivata fenantrena, te amido 47 i amidino 48 derivata nafto[2,1-b]tiofena nije bila uspješna. Amino supstituirani derivati fenantrena 30, 31, 32 i 33 priređeni su iz 9-cijano-3-fluorfenantrena 18 reakcijom nekatalizirane nukleofilne supstitucije s odgovarajućim aminima, dok je amino supstituirani derivat nafto[2,1-b]tiofena 50 priređen iz 9-cijano-3-fluornafto[2,1-b]tiofena 39. 3,9-di-(2-imidazolinil)nafto[2,1-b]tiofen dihidroklorid 49 je priređen Pinnerovom reakcijom iz cijano supstituiranog prekursora 41. Strukture svih novo pripravljenih spojeva potvrđene su 1H NMR, 13C NMR, IR spektroskopijom i UV spektrometrijom.
Abstract (english)
The intention of this study was to synthesize new amido 26, 27, amidino 28, 29 and amino 30, 31, 32 and 33 substituted phenanthrene derivatives and amido 46, 47, amidino 48, 49 and amino 50 substituted derivatives of naphtho[2,1-b]thiophene. For the synthesis of target compounds classical methods of organic synthesis, microwave assisted synthesis and photochemical synthesis were used. Synthesis of amido 26, 27 and amidino 28, 29 derivatives of phenanthrene, amido 47 and amidino 48 derivatives of naphtho[2,1-b]thiophene was not successful. Amino substituted phenanthrene derivatives 30, 31, 32 and 33 were prepared from 9-cyano-3-fluorophenanthrene 18 in the uncatalyzed nucleophilyc substitution reaction with the appropriate amines, and amino substituted naphtho[2,1-b]thiophene 50 was prepared from 9-cyano-3-fluoronafto[2,1-b]thiophene 39. 3,9-di-(2-imidazolinyl)naphtho[2,1-b]thiophene dihydrochloride 49 was prepared by Pinner reaction from the cyano substituted precursor 41. The structures of all newly synthesizes compounds were confirmed by means of 1H NMR, 13C NMR, IR spectroscopy and UV spectrometry.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:149:348668
Study programmeTitle: Applied Chemistry - Graduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry
Course: Applied organic chemistry
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra primijenjene kemije (magistar/magistra primijenjene kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2017-10-02 11:38:19